Ondansetron Hydrochloride Dihydrate , ≥98%(HPLC) , 103639-04-9

Synonym(s):
1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one hydrochloride;GR 38032F;Ondansetron hydrochloride dihydrate

CAS NO.：103639-04-9

Empirical Formula: C18H19N3O·HCl·2H2O

Molecular Weight: 365.85

MDL number: MFCD00833882

EINECS: 600-465-5

PRODUCT Properties

• Melting point: 231-232 C
• storage temp.: -20°C
• solubility: H2O: >5mg/mL
• form: powder
• color: white
• Water Solubility: H2O: >5mg/mL
• InChI: InChI=1S/C18H19N3O.ClH.H2O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2;;/h3-6,9-10,13H,7-8,11H2,1-2H3;1H;1H2
• InChIKey: FELGMEQIXOGIFQ-ZDUSSCGKSA-N
• SMILES: O=C1C(CCC2N(C)C3=CC=CC=C3C1=2)CN1C=CN=C1C.Cl.O
• CAS DataBase Reference: 103639-04-9(CAS DataBase Reference)

Description and Uses

Ondansetron hydrochloride is a selective 5HT3-antagonist approved for the management of nausea and vomiting induced by cancer chemotherapy and radiotherapy. It is reported to have a superior side-effect profile compared with metoclopramide, representing an important advance in the treatment of nausea and vomiting associated with chemotherapy. Ondansetron hydrochloride is the first specific 5HT3-antagonist to reach the market. It is also under investigation for a number of other indications, including anxiety and schizophrenia.

A serotonin type 3 receptor antagonist.

Safety

• Symbol(GHS): GHS05,GHS06,GHS09
• Signal word: Danger
• Hazard statements: H301-H318-H410
• Precautionary statements: P273-P280-P301+P310+P330-P305+P351+P338+P310
• Hazard Codes: T,Xi
• Risk Statements: 25-36/37/38-50/53-41
• Safety Statements: 45-37/39-26-61-39
• RIDADR: UN 2811
• WGK Germany: 3
• RTECS: FE6375500
• HazardClass: 6.1
• PackingGroup: III
• HS Code: 2933290000
• Limited Quantities: 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
• Excepted Quantities: Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)