Orlistat , >97.0%(HPLC) , 96829-58-2

Synonym(s):
(−)-Tetrahydrolipstatin;N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester;Orlistat;Ro-18-0647

CAS NO.：96829-58-2

Empirical Formula: C29H53NO5

Molecular Weight: 495.73

MDL number: MFCD05662360

EINECS: 639-755-1

PRODUCT Properties

• Melting point: <50 °C
• Boiling point: 615.9±30.0 °C(Predicted)
• alpha: D20 -32.0° (c = 1 in chloroform)
• Density: 0.976±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: 19 mg/mL
• form: solid
• pka: 14.59±0.23(Predicted)
• color: white
• biological source: synthetic (organic)
• Merck: 14,6869
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
• InChIKey: AHLBNYSZXLDEJQ-FWEHEUNISA-N
• SMILES: C(O[C@H](C[C@H]1[C@H](CCCCCC)C(=O)O1)CCCCCCCCCCC)(=O)[C@H](CC(C)C)NC=O
• CAS DataBase Reference: 96829-58-2(CAS DataBase Reference)

Description and Uses

Orlistat was launched in the UK as Xenical for the long-term treatment of obesity, preferably in conjunction with a moderately reduced calorie diet. Orlistat is a tetrahydro-derivative of the natural hypolipaemic lipstatin (from Streptomyces toxyfncini) and can be obtained either by hydrogenation of lipstatine or by several different synthetic ways involving many steps from ( S ) - rnalic acid. Orlistat is a potent inhibitor of gastrointestinal lipases required for the lipolysis and digestion of dietary fat, in particular of pancreatic lipase ; as a result, it prevents the absorption of about one third of the fat contained in food and acts as an effective weight-reducing therapy. The outcomes of several clinical trials involving thousands of obese patients showed that Orlistat promotes a significant weight loss (often between 5 and 10% after one year) and improves cardiovascular risk factors such as total cholesterol, LDL/HDL ratio, blood glucose levels, insulin, blood pressure. Orlistat has minimal systemic absorption, the majority of the compound itself being recovered in the feces ; it does not affect other gastrointestinal processes, or the absorption of other rnacronutrients such as carbohydrates and proteins.

Orlistat is an antiobesity agent. Orlistat is an pancreatic lipase inhibitor.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H412
• Precautionary statements: P273
• PPE: Eyeshields, Gloves, type N95 (US)
• WGK Germany: 3
• RTECS: OH3167600
• HS Code: 29322090
• Storage Class: 11 - Combustible Solids
• Hazardous Substances Data: 96829-58-2(Hazardous Substances Data)