A6663712
Phenyl chloroformate , 98% , 1885-14-9
Synonym(s):
Chloroformic acid phenyl ester;Chloroformic acid phenyl ester, Phenyl chlorocarbonate;Phenyl chloroformate
CAS NO.：1885-14-9
Empirical Formula: C7H5ClO2
Molecular Weight: 156.57
MDL number: MFCD00000637
EINECS: 217-547-8
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | -28 °C |
| Boiling point: | 74-75 °C/13 mmHg (lit.) |
| Density | 1.248 g/mL at 25 °C (lit.) |
| vapor density | 1 (vs air) |
| vapor pressure | 1.22 psi ( 20 °C) |
| refractive index | n |
| Flash point: | 168 °F |
| storage temp. | 2-8°C |
| solubility | Miscible with N,N-dimethylformamide. |
| form | Liquid |
| color | Clear |
| Water Solubility | hydrolysis |
| Sensitive | Moisture Sensitive |
| BRN | 606778 |
| InChI | 1S/C7H5ClO2/c8-7(9)10-6-4-2-1-3-5-6/h1-5H |
| InChIKey | AHWALFGBDFAJAI-UHFFFAOYSA-N |
| SMILES | ClC(=O)Oc1ccccc1 |
| CAS DataBase Reference | 1885-14-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Carbonochloridic acid, phenyl ester(1885-14-9) |
| EPA Substance Registry System | Carbonochloridic acid, phenyl ester (1885-14-9) |
Description and Uses
Phenyl chloroformate is used in the synthesis of poly(2-(phenoxycarbonyloxy)ethyl methacrylate) and phenyl-(4-vinylphenyl) carbonate. It acts as a precursor of phenyl mixed anhydrides which are used in peptide coupling reactions. It serves as a dehydrating reagent for the conversion of primary amides to nitriles and an intermediate in the synthesis of pharmaceuticals and carbamates.
Safety
| Symbol(GHS) |   GHS05,GHS06 |
| Signal word | Danger |
| Hazard statements | H330-H302-H313-H314-H227-H290 |
| Precautionary statements | P501-P270-P260-P210-P234-P271-P264-P280-P284-P370+P378-P390-P312-P303+P361+P353-P301+P330+P331-P363-P301+P312+P330-P304+P340+P310-P305+P351+P338+P310-P403+P233-P403+P235-P406-P405 |
| target organs | Respiratory system |
| PPE | Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter |
| Hazard Codes | T+ |
| Risk Statements | 22-26-34-41-38-29-37 |
| Safety Statements | 26-28-36/37/39-45-28A |
| RIDADR | UN 2746 |
| WGK Germany | 3 |
| RTECS | FG3850000 |
| F | 10-19-21 |
| Autoignition Temperature | 540 °C |
| TSCA | TSCA listed |
| HazardClass | 6.1 |
| PackingGroup | II |
| HS Code | 29159020 |
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
| Hazard Classifications | Acute Tox. 1 Inhalation Acute Tox. 4 Oral Met. Corr. 1 Skin Corr. 1B STOT SE 3 |
| Toxicity | LD50 orally in Rabbit: 1730 mg/kg LD50 dermal Rabbit 4880 mg/kg |
| REACH Registrations | Active |
| Limited Quantities | 100ml (liquid) or 0.5 Kg (solid) |
| Excepted Quantities | Max Inner Pack (1g or 1ml) and Max Outer Pack (500g or 500ml) |
