4-Pyridinecarbonitrile , 98% , 100-48-1

Synonym(s):
4-Cyanopyridine;Isonicotinic acid nitrile;Isonicotinonitrile

CAS NO.：100-48-1

Empirical Formula: C6H4N2

Molecular Weight: 104.11

MDL number: MFCD00006417

EINECS: 202-856-2

PRODUCT Properties

• Melting point: 76-79 °C(lit.)
• Boiling point: 196 °C
• Density: 1.1145 (rough estimate)
• vapor pressure: 41.9Pa at 25℃
• refractive index: 1.5242 (estimate)
• Flash point: 88 °C
• storage temp.: Sealed in dry,Room Temperature
• solubility: 40g/l
• form: Crystals or Powder
• pka: pK1:1.90(+1) (25°C)
• color: White to off-white
• Water Solubility: 3.2 g/100ml (16.4 ºC)
• BRN: 107712
• Exposure limits: NIOSH: IDLH 25 mg/m3
• Stability: Stable. Incompatible with strong bases, strong oxidizing agents, strong acids.
• InChIKey: GPHQHTOMRSGBNZ-UHFFFAOYSA-N
• LogP: 0.46 at 25℃
• CAS DataBase Reference: 100-48-1(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyridinecarbonitrile(100-48-1)
• EPA Substance Registry System: 4-Pyridinecarbonitrile (100-48-1)

Description and Uses

4-Cyanopyridine is used as an intermediate in organic synthesis and pharmaceutical substances like isonicotinylhydrazide, which is used in the treatment of tuberculosis. It is used as a precursor for the preparation of isonicotinic acid and 4-diemthylaminopyridine (DMAP). It is involved in the synthesis of 6-methyl-2-pyridin-4-yl-pyrimidin-4-ylamine by reacting with acetonitrile.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302+H312+H332
• Precautionary statements: P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312
• Hazard Codes: Xn
• Risk Statements: 20/21/22
• Safety Statements: 36/37-24/25
• RIDADR: 3276
• WGK Germany: 3
• TSCA: Yes
• PackingGroup: III
• HS Code: 29333999