4-Piperidinecarboxamide , 98% , 39546-32-2

Synonym(s):
Hexahydroisonicotinamide;Isonipecotamide

CAS NO.：39546-32-2

Empirical Formula: C6H12N2O

Molecular Weight: 128.17

MDL number: MFCD00038012

EINECS: 254-501-6

PRODUCT Properties

• Melting point: 145-148 °C(lit.)
• Boiling point: 237.61°C (rough estimate)
• Density: 1.0754 (rough estimate)
• refractive index: 1.4880 (estimate)
• storage temp.: Keep in dark place,Inert atmosphere,Room temperature
• solubility: DMSO (Sparingly), Methanol (Slightly)
• pka: 16.48±0.20(Predicted)
• form: Crystalline Powder
• color: White to light yellow
• Water Solubility: Soluble in water.
• Sensitive: Hygroscopic
• BRN: 112554
• Stability: Hygroscopic
• InChIKey: DPBWFNDFMCCGGJ-UHFFFAOYSA-N
• LogP: -0.88
• CAS DataBase Reference: 39546-32-2(CAS DataBase Reference)
• EPA Substance Registry System: 4-Piperidinecarboxamide (39546-32-2)

Description and Uses

Isonipecotamide is used as a reactant for the preparation of Survival motor neuron (SMN) protein modulators, orally available naphthyridine protein kinase D inhibitors and heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase. It is also used to prepare phosphodiesterase 5 inhibitors. It is also used as a reactant for identification of small molecular inhibitors of importin-beta mediated nuclear import. It is also used as a fluorenylmethyloxycarbonyl - deprotection agent in organic synthesis.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-37/39-36
• WGK Germany: 3
• Hazard Note: Irritant
• TSCA: Yes
• HS Code: 29339900