PD0325901 , ≥99% , 391210-10-9

Synonym(s):
InSolution MEK1/2 Inhibitor III, PD0325901 - CAS 391210-10-9 - Calbiochem;MEK1/2 Inhibitor III - CAS 391210-10-9 - Calbiochem;N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide;PD 0325901, N-((2R)-2,3-Dihyroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-benzamide, PD325901;PD325901, PD0325901, N-((2R)-2,3-Dihyroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-benzamide, PD 0325901, MEK Inhibitor III

CAS NO.：391210-10-9

Empirical Formula: C16H14F3IN2O4

Molecular Weight: 482.19

MDL number: MFCD08435926

EINECS: 687-152-7

PRODUCT Properties

• Melting point: 112-114°C
• Density: 1.817±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: soluble20mg/mL, clear
• form: White to off-white solid
• pka: 13.45±0.20(Predicted)
• color: white to off-white
• optical activity: [α]/D -1.8 to -3.5°, c = 1 mg/mL in methanol
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
• InChI: InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1
• InChIKey: SUDAHWBOROXANE-SECBINFHSA-N
• SMILES: C(NOC[C@H](O)CO)(=O)C1=CC=C(F)C(F)=C1NC1=CC=C(I)C=C1F

Description and Uses

PD 325901 (391210-10-9) is a selective non-ATP competitive MEK inhibitor (IC50 = 0.33 nM).1 Inhibits growth and/or proliferation of a variety of cancer cells.2 Enhances self-renewal of embryonic stem cells.3 In combination with vitamin C, synergistically induces hypomethylation of mouse embryonic stem cells.4 In combination with CHIR-99021 and A83-01 induces generation of ground state iPS cells from human and rat somatic cells.5

PD 0325901 has been used as an inhibitor in extracellular signal-regulated kinase (ERK) inhibition assay in primed induced pluripotent stem cells, RKO colorectal cancer cell line and human embryonic stem cells(hESCs).

Safety

• Symbol(GHS): GHS06,GHS08
• Signal word: Danger
• Hazard statements: H301-H373-H413
• Precautionary statements: P260-P264-P270-P273-P301+P310-P314
• Hazard Codes: T,N
• Risk Statements: 25-48-50
• Safety Statements: 22-36/37/39-61
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• HazardClass: IRRITANT
• HS Code: 29242990
• Storage Class: 10 - Combustible liquids