PD0325901 , ≥99% , 391210-10-9
Synonym(s):
InSolution MEK1/2 Inhibitor III, PD0325901 - CAS 391210-10-9 - Calbiochem;MEK1/2 Inhibitor III - CAS 391210-10-9 - Calbiochem;N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide;PD 0325901, N-((2R)-2,3-Dihyroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-benzamide, PD325901;PD325901, PD0325901, N-((2R)-2,3-Dihyroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-benzamide, PD 0325901, MEK Inhibitor III
CAS NO.：391210-10-9
Empirical Formula: C16H14F3IN2O4
Molecular Weight: 482.19
MDL number: MFCD08435926
EINECS: 687-152-7
| Pack Size | Price | Stock | Quantity |
| 5MG | RMB375.20 | In Stock |
|
| 25MG | RMB719.20 | In Stock |
|
| 100MG | RMB2119.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 112-114°C |
| Density | 1.817±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble20mg/mL, clear |
| form | White to off-white solid |
| pka | 13.45±0.20(Predicted) |
| color | white to off-white |
| optical activity | [α]/D -1.8 to -3.5°, c = 1 mg/mL in methanol |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| InChI | InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1 |
| InChIKey | SUDAHWBOROXANE-SECBINFHSA-N |
| SMILES | C(NOC[C@H](O)CO)(=O)C1=CC=C(F)C(F)=C1NC1=CC=C(I)C=C1F |
Description and Uses
PD 325901 (391210-10-9) is a selective non-ATP competitive MEK inhibitor (IC50 = 0.33 nM).1 Inhibits growth and/or proliferation of a variety of cancer cells.2 Enhances self-renewal of embryonic stem cells.3 In combination with vitamin C, synergistically induces hypomethylation of mouse embryonic stem cells.4 In combination with CHIR-99021 and A83-01 induces generation of ground state iPS cells from human and rat somatic cells.5
PD 0325901 has been used as an inhibitor in extracellular signal-regulated kinase (ERK) inhibition assay in primed induced pluripotent stem cells, RKO colorectal cancer cell line and human embryonic stem cells(hESCs).
Safety
| Symbol(GHS) |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H301-H373-H413 |
| Precautionary statements | P260-P264-P270-P273-P301+P310-P314 |
| Hazard Codes | T,N |
| Risk Statements | 25-48-50 |
| Safety Statements | 22-36/37/39-61 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 29242990 |
