PLX-4720 , ≥99% , 918505-84-7

CAS NO.：918505-84-7

Empirical Formula: C17H14ClF2N3O3S

Molecular Weight: 413.83

MDL number: MFCD14635203

PRODUCT Properties

• Melting point: 230-233oC
• Density: 1.55
• storage temp.: +2C to +8C
• solubility: DMSO (Slightly), Methanol (Slightly, Heated)
• form: Orange-yellow solid
• pka: 6.20±0.10(Predicted)
• color: White to Off-White

Description and Uses

The Raf kinases activate cellular pathways that lead to cell proliferation and can contribute to certain types of cancer. Mutations in the kinase B-Raf are involved in a wide range of cancers. In particular, the mutation B-Raf^V600E occurs in melanomas and thyroid cancer but is poorly targeted by many inhibitors of wild type B-Raf. PLX4720 is an orally-available, highly selective inhibitor of B-Raf^V600E (IC₅₀ = 13 nM). It is less effective against wild type B-Raf (IC₅₀ = 160 nM) as well as several other kinases. PLX4720 induces cell cycle arrest and apoptosis in cells and xenografts expressing the mutant of B-Raf.

A potent and selective inhibitor of B-RafV600E and c-Raf-1Y340D/Y341D with IC50s of 13 nM and 6.7 nM, respectively.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338