Birinapant , 10mMinDMSO , 1260251-31-7
CAS NO.：1260251-31-7
Empirical Formula: C42H56F2N8O6
Molecular Weight: 806.94
MDL number: MFCD25976869
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB559.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | >245oC (dec.) |
| Boiling point: | 1090.5±65.0 °C(Predicted) |
| Density | 1.320±0.06(20.0000℃) |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| pka | 13.99±0.46(Predicted) |
| form | Solid |
| color | White to Off-White |
| InChIKey | PKWRMUKBEYJEIX-AUTGSTJINA-N |
Description and Uses
Birinapant is a bivalent mimetic of the Diablo homolog known as second mitochondria-derived activator of caspase (Smac). It is an antagonist of cellular inhibitor of apoptosis 1 (cIAP1, or BIRC2), cIAP2 (BIRC3), and XIAP (BIRC4), binding each at nanomolar concentrations. Birinapant causes rapid cIAP1 degradation, caspase activation, PARP cleavage, and NF-κB activation in breast cancer cells. It shows in vivo antitumor activity, inducing apoptosis in several types of cancer xenografts in mice.
Birinapant is a bivalent SMAC mimetic compound antagonist of TRAF2 associated cIAP1 and cIAP2.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P305+P351+P338 |
| HS Code | 29339900 |
