Dexrazoxane , 10mMinDMSO , 24584-09-6

Synonym(s):
(+)-(S)-4,4′-Propylenedi-2,6-piperazinedione;(S)-(+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane;Cardioxane;Zinecard

CAS NO.：24584-09-6

Empirical Formula: C11H16N4O4

Molecular Weight: 268.27

MDL number: MFCD00866449

PRODUCT Properties

• Melting point: 194-196°C
• alpha: D +11.35° (c = 5 in DMF)
• Boiling point: 531.5±50.0 °C(Predicted)
• Density: 1.333±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: >20mg/mL
• pka: 2.1(at 25℃)
• form: powder
• color: white to off-white
• Merck: 14,8123
• Henry's Law Constant: 4.7×10¹³ mol/(m³Pa) at 25℃, HSDB (2015)
• Major Application: clinical testing
• InChI: InChI=1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1
• InChIKey: BMKDZUISNHGIBY-ZETCQYMHSA-N
• SMILES: [C@H](N1CC(=O)NC(=O)C1)(C)CN1CC(=O)NC(=O)C1
• CAS DataBase Reference: 24584-09-6(CAS DataBase Reference)

Description and Uses

Dexrazoxane is the dextro-isomer of razoxane approved as a protectant against the cardiotoxicity of doxorubicin in breast cancer patients. This agent does not alter the anticancer effect of doxorubicin. Its mode of action suggests a chelation of free radicals. In mice, dexrazoxane also offers protection against cardiac side effects of epirubicin, but not mitoxantrone.

Cardioprotectant.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• target organs: Respiratory system
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• RTECS: TL6390000
• HS Code: 2933.59.9500
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Eye Irrit. 2; Skin Irrit. 2; STOT SE 3
• Hazardous Substances Data: 24584-09-6(Hazardous Substances Data)