ICRF-186 , 0.95 , 24613-06-7

CAS NO.：24613-06-7

Empirical Formula: C11H16N4O4

Molecular Weight: 268.27

MDL number: MFCD00870253

PRODUCT Properties

• Boiling point: 531.5±50.0 °C(Predicted)
• Density: 1.333±0.06 g/cm3(Predicted)
• pka: 11.00±0.20(Predicted)
• InChI: InChI=1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m1/s1
• InChIKey: BMKDZUISNHGIBY-SSDOTTSWSA-N
• SMILES: [C@@H](N1CC(=O)NC(=O)C1)(C)CN1CC(=O)NC(=O)C1

Description and Uses

(R)-Levrazoxane ((R)-ICRF 186) is enzymatically hydrolysed to one-ring open intermediates by dihydropyrimidine amidohydrolase (DPHase), which is present in the liver and kidney. The radiosensitizing efficiency of (R)-Levrazoxane towards EMT6 mouse mammary tumour cells is greater than that of Dexrazoxane (HY-B0581). (R)-Levrazoxane is promising for research of liver and kidney related diseases[1].

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H302+H312+H332
• Precautionary statements: P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P