DL-Thiocticacid , 10mMinDMSO , 1077-28-7

Synonym(s):
Thioctic acid;DL-Thioctic Acid;(±)-1,2-Dithiolane-3-pentanoic acid;6,8-Dithiooctanoic acid;DL-α-Lipoic acid

CAS NO.：1077-28-7

Empirical Formula: C8H14O2S2

Molecular Weight: 206.33

MDL number: MFCD00005474

EINECS: 214-071-2

PRODUCT Properties

• Melting point: 60-62 °C
• Boiling point: 160-165 °C(lit.)
• Density: 1.2888 (rough estimate)
• bulk density: 260kg/m3
• refractive index: 1.5200 (estimate)
• Flash point: 160-165°C
• storage temp.: 2-8°C
• solubility: ethanol: 50 mg/mL
• form: Crystals or Crystalline Powder
• pka: 4.75±0.10(Predicted)
• color: Yellow
• biological source: synthetic
• Water Solubility: 0.9 g/L (20 ºC)
• Merck: 14,9326
• BRN: 81853
• Stability: Stable. Incompatible with strong oxidizing agents.
• InChIKey: AGBQKNBQESQNJD-UHFFFAOYSA-N
• LogP: 2.530 (est)
• CAS DataBase Reference: 1077-28-7(CAS DataBase Reference)
• NIST Chemistry Reference: Dl-thioctic acid(1077-28-7)

Description and Uses

DL-α-Lipoic acid is a cyclic disulfide antioxidant that interconverts with its reduced dithiol form. It is an essential cofactor for decarboxylation reactions of the citric acid cycle, and acts as a general antioxidant. DL-α-lipoic acid can act as a direct radical scavenger, as a cofactor to regenerate reduced glutathione, and as a metal chelator.

Lipoic acid [CAS: 1077-28-7] (6,8-dimercaptooctanoic acid), a lipophilic endogenous disulfide that can be reduced to the dithiol dihydrolipoic acid, protects against free-radical-mediated injury both in vivo and in vitro.

Safety

• Symbol(GHS): GHS07,GHS09
• Signal word: Warning
• Hazard statements: H302-H315-H317-H319-H411
• Precautionary statements: P261-P273-P280-P301+P312-P302+P352-P305+P351+P338
• Hazard Codes: Xn
• Risk Statements: 22-20/21/22
• Safety Statements: 37/39-26-24/25-36-36/37/39
• WGK Germany: 3
• RTECS: JP1192000
• HS Code: 29349990
• Hazardous Substances Data: 1077-28-7(Hazardous Substances Data)