Carmofur , 10mMinDMSO , 61422-45-5
Synonym(s):
1-Hexylcarbamoyl-5-fluorouracil;HCFU
CAS NO.：61422-45-5
Empirical Formula: C11H16FN3O3
Molecular Weight: 257.26
MDL number: MFCD00866284
EINECS: 689-431-9
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB559.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 110-111 |
| Density | 1.2287 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO: >15mg/mL |
| form | powder |
| pka | 6.94±0.10(Predicted) |
| color | white to off-white |
| Merck | 14,1844 |
| InChI | 1S/C11H16FN3O3/c1-2-3-4-5-6-13-10(17)15-7-8(12)9(16)14-11(15)18/h7H,2-6H2,1H3,(H,13,17)(H,14,16,18) |
| InChIKey | AOCCBINRVIKJHY-UHFFFAOYSA-N |
| SMILES | CCCCCCNC(=O)N1C=C(F)C(=O)NC1=O |
| CAS DataBase Reference | 61422-45-5(CAS DataBase Reference) |
Description and Uses
Carmofur is an inhibitor of acid ceramidase (IC50 = 79 nM for the rat enzyme) and a derivative of 5-flurouracil . It reduces acid ceramidase activity in a dose- and time-dependent manner and induces intracellular accumulation of various ceramide species, including C18 ceramide , C16 ceramide , and C14 ceramide in SW403 colon and LNCaP prostate cancer cells. Carmofur induces apoptosis in SW403 cells without inhibiting DNA synthesis (IC50 = 1,212 mM for human thymidylate synthetase). It also reduces acid ceramidase activity and increases ceramide accumulation in mouse lung and brain when administered at doses of 10 and 30 mg/kg.
antineoplastic
Safety
| Symbol(GHS) |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H301-H361 |
| Precautionary statements | P201-P301+P310+P330 |
| Hazard Codes | Xi,T |
| Risk Statements | 60-61-25 |
| Safety Statements | 45 |
| RIDADR | UN 2811 6.1 / PGII |
| WGK Germany | 3 |
| RTECS | UV7714000 |
| Hazard Note | Irritant |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29335990 |
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
| Hazard Classifications | Acute Tox. 3 Oral Repr. 2 |
