astemizole , 10mMinDMSO , 68844-77-9

Synonym(s):
1-(4-Fluorobenzyl)-2-(1-[4-methoxyphenethyl]piperidin-4-yl)aminobenzimidazole

CAS NO.：68844-77-9

Empirical Formula: C28H31FN4O

Molecular Weight: 458.57

MDL number: MFCD00153919

EINECS: 272-441-9

PRODUCT Properties

• Melting point: 172.9°C
• Boiling point: 627.3±65.0 °C(Predicted)
• Density: 1.1587 (estimate)
• storage temp.: 2-8°C
• solubility: DMSO: >20mg/mL
• pka: pKa 4.85(H2O t=25.0 I=0.025) (Uncertain);8.69(H2O t=25.0 I=0.025) (Uncertain)
• form: powder
• color: Crystals
• Water Solubility: It is soluble in DMSO (25 mg/ml ), ethanol (25 mg/ml), chloroform, methanol, and water (partly miscible).
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
• InChI: 1S/C28H31FN4O/c1-34-25-12-8-21(9-13-25)14-17-32-18-15-24(16-19-32)30-28-31-26-4-2-3-5-27(26)33(28)20-22-6-10-23(29)11-7-22/h2-13,24H,14-20H2,1H3,(H,30,31)
• InChIKey: GXDALQBWZGODGZ-UHFFFAOYSA-N
• SMILES: COc1ccc(CCN2CCC(CC2)Nc3nc4ccccc4n3Cc5ccc(F)cc5)cc1

Description and Uses

Astemizole belongs to the second-generation class of non-sedating, non-anticholinergic antihistamines. Its non-sedating properties appear to result from its poor penetration of the blood brain barrier. As a result it shows no potentiation of CNS depressants, including alcohol. Its long half-life allows once-daily dosing.

scabicide

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• target organs: Respiratory system
• Hazard Codes: Xn
• Risk Statements: 22-36/37/38
• Safety Statements: 26-36
• RIDADR: UN 2811 6.1 / PGII
• WGK Germany: 3
• RTECS: DD8968000
• HS Code: 2933992600
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Eye Irrit. 2; Skin Irrit. 2; STOT SE 3
• Hazardous Substances Data: 68844-77-9(Hazardous Substances Data)
• Toxicity: LD50 orl-rat: >2560 mg/kg AIPTAK 251,39,81