Brazilin , 10mMinDMSO , 474-07-7
Synonym(s):
(+)-Brazilin;(6aS,11bR)-7,11b-Dihydro-benz[b]indeno[1,2-d]pyran-3,6a,9,10(6H)-tetrol;6,6a,7,11b-Tetrahydro-3,6a,9,10-tetrahydroxyindeno[2,1-c]chromene;7, 11b-dihydrobenz[b]indeno[1,2-d]pyran-3,6a,9,10 (6H)-tetrol;Brasilin
CAS NO.：474-07-7
Empirical Formula: C16H14O5
Molecular Weight: 286.28
MDL number: MFCD00210817
EINECS: 207-477-6
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB559.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 156-157℃ |
| Boiling point: | 348.65°C (rough estimate) |
| Density | 1.1924 (rough estimate) |
| refractive index | 1.6200 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO:43.5(Max Conc. mg/mL);151.95(Max Conc. mM) DMF:30.0(Max Conc. mg/mL);104.79(Max Conc. mM) Ethanol:30.0(Max Conc. mg/mL);104.79(Max Conc. mM) PBS (pH 7.2):10.0(Max Conc. mg/mL);34.93(Max Conc. mM) |
| Colour Index | 75280 |
| pka | 9.870±0.40(predicted) |
| form | A crystalline solid |
| color | Yellow to brown |
| optical activity | [α]/D 108.0 to 133.0°, c =0.5 in methanol |
| InChI | InChI=1S/C16H14O5/c17-9-1-2-10-14(4-9)21-7-16(20)6-8-3-12(18)13(19)5-11(8)15(10)16/h1-5,15,17-20H,6-7H2 |
| InChIKey | UWHUTZOCTZJUKC-UHFFFAOYSA-N |
| SMILES | C12C3C=CC(O)=CC=3OCC1(O)CC1=CC(O)=C(O)C=C21 |
| EPA Substance Registry System | Brazilin (474-07-7) |
Description and Uses
Brazilin is an isoflavonoid originally isolated from C. sappan that has diverse biological activities, including neuroprotective, anti-inflammatory, antibacterial, and antioxidant properties. Brazilin inhibits Aβ (1-42) fibrillogenesis (IC50 = 1.5 μM) more potently than (-)-epigallocatechin gallate , cucurmin , and resveratrol. It also prevents remodeling of mature Aβ (1-42) fibrils. Brazilin inhibits the production of cytokines, including PGE2 and TNF-α (IC50s = 12.6 and 87.2 μM). It is effective against Gram-positive and Gram-negative bacteria with MICs ranging from 31.3 to 250 μg/ml. In addition, brazilin inhibits osteoclast differentiation mediated by RANKL and is protective against LPS-induced osteoporosis in mice at a dose of 100 mg/kg.
Brazilin family of natural products.
inhibits platelet aggregation, PLA2, PKC, protein phosphatase, insulin receptor kinase, nitric oxide synthase, antineoplastic
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| Safety Statements | 24/25 |
| WGK Germany | WGK 3 |
| TSCA | TSCA listed |
| HS Code | 29329990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
