A7101412
Quizartinib (AC220) , ≥99% , 950769-58-1
CAS NO.：950769-58-1
Empirical Formula: C29H32N6O4S
Molecular Weight: 560.67
MDL number: MFCD18074524
| Pack Size | Price | Stock | Quantity |
| 5MG | RMB511.20 | In Stock |
|
| 10MG | RMB827.28 | In Stock |
|
| 50MG | RMB2311.20 | In Stock |
|
| 500mg | RMB9520.00 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Density | 1.39±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to at least 25 mg/ml) |
| form | White powder. |
| pka | 12.59±0.70(Predicted) |
| color | Off-white |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| InChIKey | CVWXJKQAOSCOAB-UHFFFAOYSA-N |
| SMILES | N(C1C=C(C(C)(C)C)ON=1)C(NC1=CC=C(C2=CN3C4=CC=C(OCCN5CCOCC5)C=C4SC3=N2)C=C1)=O |
Description and Uses
Quizartinib is an oral, highly potent, and selective next-generation FLT3 inhibitor (Kd= 1.6nM, IC50= 0.56 nM MV4-11 cells) with clinical antileukaemic activity in relapsed or refractory acute myeloid leukaemia. Quizartinib priming resulted in prevention of myelosuppression in mice treated with 5-FU and Gemcitabine. Quizartinib showed significant reversal of ABCG2-mediated multidrug resistance (@ 3 μM) via antagonism of drug efflux function.?
AC 220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P260-P280-P301+P312-P302+P352-P304+P340-P361+P364 |
| HS Code | 2914500090 |
