A7111912
Radicicol , 98% , 12772-57-5
Synonym(s):
[1aS-(1aR*,2Z,4E,14*,15aR*)]-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione;Monorden;Radicicol, Diheterospora chlamydosporia - CAS 12772-57-5 - Calbiochem
| Pack Size | Price | Stock | Quantity |
| 1MG | RMB799.20 | In Stock |
|
| 5MG | RMB2959.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 193.5° |
| alpha | D20 +203° (chloroform) |
| Boiling point: | 656.2±55.0 °C(Predicted) |
| Density | 1.364±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | ethanol: 10 mg/mL |
| form | solid |
| pka | 6.29±0.40(Predicted) |
| color | yellow |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
Description and Uses
Radicicol (12772-57-5) inhibits heat shock protein 90 (HSP90) activity by binding to the ATP-binding pocket.1?In cells HSP90 client proteins such as Raf kinase2, HIF-1α3?and estrogen receptor4?are destabilized and proteolytically degraded. Radicicol inhibits expression of COX-2 without affecting COX-1 expression in LPS-stimulated macrophages (IC50=27 nM).5?Inhibits angiogenesis.6
Radicicol from Diheterospora chlamydosporia has been used as an inhibitor of heat shock protein 90 (Hsp90):
- to study its effects on lifespan extension and health in Caenorhabditis elegans
- to study its effects on protein aggregation in yeast
- to study its effects on xanthone sensitized cancer cells
Safety
| Symbol(GHS) |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H301-H340-H350 |
| Precautionary statements | P202-P264-P270-P280-P301+P310-P405 |
| Hazard Codes | Xn,T |
| Risk Statements | 22-36/37/38-46-45 |
| Safety Statements | 26-45-53 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 1 |
| RTECS | RR1105000 |
| HS Code | 29322090 |
| Toxicity | mouse,LD50,intravenous,175mg/kg (175mg/kg),"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 2, Pg. 448, 1980. |
