RG108 , ≥98% , 48208-26-0
| Pack Size | Price | Stock | Quantity |
| 10MG | RMB150.40 | In Stock |
|
| 50MG | RMB262.40 | In Stock |
|
| 250MG | RMB1119.20 | In Stock |
|
| 1g | RMB2239.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 192-194℃ |
| Boiling point: | 606.0±50.0 °C(Predicted) |
| Density | 1.502±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: >10mg/mL |
| pka | 3.62±0.10(Predicted) |
| form | powder |
| color | yellow |
| optical activity | [α]/D -250 to -310°, c =0.5 in methanol |
| Sensitive | Light Sensitive |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| CAS DataBase Reference | 48208-26-0 |
Description and Uses
RG-108 (48208-26-0) is a non-nucleoside DNA methyltransferase inhibitor. IC50=115 nM1 Inhibits DNA methylation in human tumor cell lines without toxicity2. RG-108 enhances the reversion of neural progenitor cells to the pluripotent state.3
DNA methylation regulates gene expression in normal and malignant cells. RG-108 is a non-nucleoside DNA methyltransferase inhibitor (IC50 = 115 nM in vitro). It significantly reduces the methylation of genomic DNA in cells at 10 μM without detectable toxicity, distinguishing it from nucleoside-based inhibitors like 5-azacytidine. Further, RG-108 inhibits DNA methyltransferase activity by blocking the enzyme active site. Through these actions, RG-108 demethylates and reactivates epigenetically silenced tumor suppressor genes.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501 |
| WGK Germany | 3 |
| HS Code | 2933.99.9701 |
