Ribonuclease A from bovine pancreas(DNase & Protease Free) , ≥2,000units/mgprotein , 9001-99-4

Synonym(s):
RNase A;Rnase;Ribonuclease A;RNAsea;RNase B

CAS NO.：9001-99-4

Empirical Formula: NULL

Molecular Weight:

MDL number: MFCD00132188

EINECS: 232-646-6

PRODUCT Properties

• Melting point: 243 °C (dec.)
• alpha: D25 (per mg N) -0.47° (c = 5)
• storage temp.: -20°C
• solubility: Reconstitute in 10mM acetate, pH 5.0 with or without 15mM calcium chloride
• form: solid
• color: white
• PH: pH : 8.0
• biological source: protein from bovine pancreas
• Water Solubility: Soluble in water.
• Sensitive: Moisture Sensitive
• Specific Activity: 85-140Kunitz units/mg protein
• Major Application: diagnostic assay manufacturing
• InChI: 1S/C9H14N4O3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16)
• InChIKey: CQOVPNPJLQNMDC-UHFFFAOYSA-N
• SMILES: [nH]1cnc(c1)CC(NC(=O)CCN)C(=O)O
• EPA Substance Registry System: Nuclease, ribo- (9001-99-4)

Description and Uses

Ribonuclease A (RNase A) is a pancreatic ribonuclease that cleaves single-stranded RNA. RNase A, and several homologs, may be useful as cancer therapeutics due to their cytotoxic effects on cancer cells. Rnase A is useful in the elucidation of protein structure and absorbance. RNase A has been used as a model system in the study of computer-aided drug design . Product R2638 has scrambled disulfide bonds and is from bovine pancreas.

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H334
• Precautionary statements: P261-P284-P501
• PPE: Eyeshields, Gloves, type N95 (US)
• Safety Statements: 22-24/25
• WGK Germany: 3
• RTECS: RF0760000
• F: 10-21
• TSCA: TSCA listed
• HS Code: 35079090
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Resp. Sens. 1