Imipenem monohydrate , ≥95%(HPLC) , 74431-23-5

Synonym(s):
(5R,6S)-6-[(1R)-1-Hydroxyethyl]-3-[[2-[(iminomethyl)amino]ethyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monohydrate;Imipenem monohydrate;Primaxin monohydrate;Tienam monohydrate

CAS NO.：74431-23-5

Empirical Formula: C12H19N3O5S

Molecular Weight: 317.36

MDL number: MFCD00864955

EINECS: 680-398-6

PRODUCT Properties

• Melting point: 193-198°C
• Boiling point: 567℃
• RTECS: CL5446516
• Flash point: >110°(230°F)
• storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• solubility: H2O: >5mg/mL
• pka: pKa 3.2/9.9(H2O,t = 25) (Uncertain)
• form: powder
• color: white to beige
• optical activity: [α]/D +73 to +84°, c =0.5 in water
• Water Solubility: Soluble in water at 5mg/ml
• InChI: InChI=1/C12H17N3O4S.H2O/c1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17;/h5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19);1H2/t6-,7-,9-;/s3
• InChIKey: GSOSVVULSKVSLQ-ONZDYIGBNA-N
• SMILES: C(C1=C(C[C@]2([H])[C@@]([H])([C@H](O)C)C(=O)N12)SCCNC=N)(=O)O.O |&1:4,6,8,r|
• CAS DataBase Reference: 74431-23-5(CAS DataBase Reference)

Description and Uses

Imipenem has a broad spectrum of antimicrobial action, which includes most clinically significant microorganisms: Gram-positive, Gram-negative, aerobic, and anaerobic. It is resistant with respect to most beta-lactamases of Gram-positive and Gram-negative bacteria. It is used for bacterial infections of the lower respiratory tract, infections of the urinary and sexual tracts, infections of bones, joints, skin, soft tissues, intraabdominal and gynecological infections, bacterial septicemia, and endocarditis.
Imipenem undergoes enzymatic inactivation in the kidneys. In order to avoid this problem, it is used in a 1:1 ratio in combination with cilastatin—the sodium salt of [R-[R,S-(Z)]]-7-[(2- amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl)aminocarbonyl-2-heptenoic acid (32.1.3.6), which inhibits metabolisms of imipenem in the kidneys. This combination of two compounds is also used in medicine under the name primaxin.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
• PPE: Eyeshields, Gloves, type N95 (US)
• WGK Germany: 3
• HS Code: 2941906000
• Storage Class: 11 - Combustible Solids