Dobutamine Hydrochloride , >98.0%(HPLC) , 49745-95-1

Synonym(s):
(±)-3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-β-phenethylamine hydrochloride

CAS NO.：49745-95-1

Empirical Formula: C18H24ClNO3

Molecular Weight: 337.84

MDL number: MFCD00153795

EINECS: 256-464-1

PRODUCT Properties

• Melting point: 184-186 C
• storage temp.: 2-8°C
• solubility: Sparingly soluble in water, soluble in methanol, sparingly soluble in ethanol (96 per cent).
• form: Solid
• pka: 9.45(at 25℃)
• color: White to Off-White
• Water Solubility: Soluble in water or ethanol with warming. Also soluble in methanol
• λmax: 281nm(MeOH)(lit.)
• Merck: 14,3395
• Stability: Solutions are rapidly oxidized at pH 11-13. It is recommended that solutions be freshly prepared and protected from light. Dobutamine hydrochloride is sensitive to light.
• InChI: InChI=1S/C18H23NO3.ClH/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15;/h4-9,12-13,19-22H,2-3,10-11H2,1H3;1H
• InChIKey: BQKADKWNRWCIJL-UHFFFAOYSA-N
• SMILES: C1(O)=CC=C(CCNC(C)CCC2=CC=C(O)C=C2)C=C1O.[H]Cl
• CAS DataBase Reference: 49745-95-1(CAS DataBase Reference)
• EPA Substance Registry System: 1,2-Benzenediol, 4-[2-[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]ethyl]-, hydrochloride (49745-95-1)

Description and Uses

Dobutamine hydrochloride, a dopamine derivative, is a selective β1-adrenergic agonist. It is a sympathomimetic agent with inotropic action (changes strength of muscle contraction) on the heart. However, it may have some α and β2-agonist properties as well.The active substance strengthens the contraction power of the heart, increases the stroke volume and thus the blood circulation of the organs. It is used for the treatment of acute heart failure and for cardiac stress tests.

Dobutamine Hydrochloride is a sympathomimetic drug used to treat heart failure by inhibiting β1 receptors in the sympathetic nervous system. Cardiotonic.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Warning
• Hazard statements: H302+H312+H332-H361
• Precautionary statements: P201-P280-P301+P312+P330-P302+P352+P312-P304+P340+P312-P308+P313
• PPE: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
• Hazard Codes: Xn,Xi
• Risk Statements: 20/21/22-63-36/37/38-R63-R62-R11-R21-R20
• Safety Statements: 22-26-36/37/39-36/37-S53-S39-S37-S36-S26-S22
• WGK Germany: 3
• HS Code: 29222990
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Acute Tox. 4 Dermal; Acute Tox. 4 Inhalation; Acute Tox. 4 Oral; Repr. 2
• Toxicity: LD50 i.v. in mice: ~73 mg/kg (Weber, Tuttle)