Ribociclib , 98% , 1211441-98-3

CAS NO.：1211441-98-3

Empirical Formula: C23H30N8O

Molecular Weight: 434.54

MDL number: MFCD27976795

EINECS: 1592732-453-0

PRODUCT Properties

• Boiling point: 730.8±70.0 °C(Predicted)
• Density: 1.39±0.1 g/cm3(Predicted)
• vapor pressure: 0-0Pa at 20-25℃
• storage temp.: -20°C
• solubility: Soluble in DMSO (up to 10 mg/ml)
• pka: 8.67±0.10(Predicted)
• form: solid
• color: Off-white
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
• InChIKey: RHXHGRAEPCAFML-UHFFFAOYSA-N
• SMILES: C1(NC2=NC=C(N3CCNCC3)C=C2)=NC=C2C=C(C(N(C)C)=O)N(C3CCCC3)C2=N1
• LogP: -0.8-2.3 at 20℃ and pH4-11

Description and Uses

LEE011 is a cyclin-dependent kinase (CDK) inhibitor that targets cyclin D1/CDK4 and cyclin D3/CDK6 at nanomolar concentrations. It inhibits retinoblastoma protein phosphorylation, which prevents CDK-mediated G₁-S phase transition, arresting the cell cycle in the G₁ phase, suppressing DNA synthesis, and inhibiting cancer cell growth. LEE011 has been shown to reduce proliferation in 12 of 17 human neuroblastoma-derived cell lines by inducing cytostasis (mean IC₅₀ = 306 nM in sensitive lines).

LEE 011 can be used in biological study of kinome-wide RNA interference screen reveals a role for PDK1 in acquired resistance to CDK4/6 inhibition in ER-positive breast cancer.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P280-P305+P351+P338