Scutellarin , Analysis standard , 27740-01-8

Synonym(s):
4′,5,6,7-Tetrahydroxyflavone 7-glucuronide;5,6-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl-β-D-glucopyranosiduronic acid;7-(β-D-Glucopyranuronosyloxy)-5,6-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;Breviscapin;Scutellarein-7-O-β-D-glucuronide

CAS NO.：27740-01-8

Empirical Formula: C21H18O12

Molecular Weight: 462.36

MDL number: MFCD01861503

EINECS: 1806241-263-5

PRODUCT Properties

• Melting point: 300～301℃
• Boiling point: 891.6±65.0 °C(Predicted)
• Density: 1.810±0.06 g/cm3(Predicted)
• storage temp.: Sealed in dry,2-8°C
• solubility: DMSO (Slightly), Methanol (Very Slightly, Sonicated)
• pka: 2.72±0.70(Predicted)
• form: Solid
• color: Light Yellow to Yellow
• BRN: 71779
• InChIKey: DJSISFGPUUYILV-ZWDBVKRXNA-N
• SMILES: O=C1C=C(C2C=CC(O)=CC=2)OC2=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](C(=O)O)O3)O)=C(O)C(O)=C12 |&1:16,17,18,20,22,r|
• CAS DataBase Reference: 27740-01-8(CAS DataBase Reference)

Description and Uses

Scutellarin is a flavone that has been found in S. barbata and has diverse biological activities, including anticancer, lipid lowering, antioxidative, and neurocognitive properties. It inhibits proliferation of PC-9 and H1975 non-small cell lung cancer (NSCLC) cells in a concentration-dependent manner and induces apoptosis and autophagy when used at a concentration of 160 μM, effects that can be blocked by the autophagy inhibitor HCQ . Scutellarin (30 and 60 mg/kg per day) reduces tumor growth in an H1975 mouse xenograft model. It decreases serum total cholesterol and LDL-cholesterol and increases HDL-cholesterol in a high-fat diet-induced mouse model of non-alcoholic fatty liver disease (NAFLD) when administered at doses of 25 and 50 mg/kg. It decreases hepatic malondialdehyde (MDA), glutamic-oxalacetic transaminase (GOT), and glutamic-pyruvic transaminase (GPT) activity, increases catalase (CAT) and total antioxidative capacity (T-AOC) activity, and increases the hepatic expression of PPARγ, PGC-1α, and Nrf2 in the same model. Scutellarin (5, 25, and 50 mg/kg per day) also prevents deficits in spatial and novel object memory in rats in the Y maze and novel object recognition test, respectively.

Scutellarin is an active flavonoid component from the medical plant Erigeron breviscapus (Vant) Hand-Mazz. Scutellarin is used as a micrpcirculation promoter for the treatment of cardio-cerebrovascular diseases. Studies suggest that Scutellarin has anti-cancer properties and has been shown to enhance apoptosis of tumor cells.

Safety

• Safety Statements: 24/25
• WGK Germany: 3
• HS Code: 29389090