SC-514 , ≥98% , 354812-17-2
Synonym(s):
4-Amino-[2,3"]bithiophenyl-5-carboxylic acid amide;IKK-2 Inhibitor, SC-514 - CAS 354812-17-2 - Calbiochem;SC-514
| Pack Size | Price | Stock | Quantity |
| 10MG | RMB341.60 | In Stock |
|
| 50MG | RMB967.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 209-211°C |
| Boiling point: | 399.2±42.0 °C(Predicted) |
| Density | 1.450±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | DMSO: soluble10mg/mL, clear |
| pka | 15.63±0.50(Predicted) |
| form | powder |
| color | white to light brown |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
Description and Uses
SC-514 (354812-17-2) is a reversible, competitive inhibitor of IKK2 (IC50 = 11.2 μM). Has not been demonstrated to inhibit other IKK isoforms, or other kinases. SC-514 displays dose-dependent inhibition of the transcription of NF-κB dependent genes in cell culture.1
A cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 ~3-12 μM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2). Its specificity has been confirmed using a panel of 31 other kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 > 200 μM). Shown to specifically block NF-kB-dependent gene expression, but not MAP kinase pathways, in stimulated synovial fibroblasts RASF.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| WGK Germany | 3 |
