Clopidogrel Bisulfate , ≥98% , 120202-66-6

Synonym(s):
(S)-Methyl (2-chlorophenyl)(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate hydrogensulfate;(S)-(+)-Clopidogrel bisulfate;(S)-(+)-Methyl 2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)-2-(2-chlorophenyl)acetate hydrogensulfate;Clopidogrel Bisulphate;CLP

CAS NO.：120202-66-6

Empirical Formula: C16H16ClNO2S.H2O4S

Molecular Weight: 419.9

MDL number: MFCD00876395

EINECS: 1806241-263-5

PRODUCT Properties

• Melting point: 174-176°C
• storage temp.: 2-8°C
• solubility: DMSO: ~26 mg/mL
• form: solid
• color: white
• optical activity: [α]/D +54 to +70°, c = 0.5 in methanol
• BRN: 9967887
• BCS Class: 2
• InChI: InChI=1/C16H16ClNO2S.H2O4S/c1-20-16(19)15(12-4-2-3-5-13(12)17)18-8-6-14-11(10-18)7-9-21-14;1-5(2,3)4/h2-5,7,9,15H,6,8,10H2,1H3;(H2,1,2,3,4)/t15-;/s3
• InChIKey: FDEODCTUSIWGLK-RSAXXLAASA-N
• SMILES: S(O)(O)(=O)=O.[C@@H](C1C=CC=CC=1Cl)(N1CCC2SC=CC=2C1)C(=O)OC |&1:5,r|
• CAS DataBase Reference: 120202-66-6(CAS DataBase Reference)

Description and Uses

(S)-(+)-Clopidogrel is the functional enantiomer of clopidogrel and a prodrug whose thiol metabolite antagonizes purine binding to the platelet purinergic receptor P2Y₁₂ (K_i = 316 nM in human platelets). It is metabolized by the cytochrome P450 (CYP) isoform CYP2C19 in rat liver and inhibits ADP-induced platelet aggregation ex vivo. Formulations containing (S)-(+)-clopidogrel have been used in combination with aspirin to prevent vascular ischemic events in patients with acute coronary syndromes.

An irreversible inhibitor of P2Y12.

Safety

• Symbol(GHS): GHS07,GHS05,GHS09
• Signal word: Danger
• Hazard statements: H335-H411-H362-H314
• Precautionary statements: P201-P260-P263-P264-P270-P308+P313-P260-P264-P280-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P305+P351+P338-P405-P501
• Safety Statements: 22-24/25
• RIDADR: 1759
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: II
• HS Code: 29349990