SEW2871 , >98% , 256414-75-2

Synonym(s):
5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]- 1,2,4-oxadiazole;S1P₁ Receptor Agonist, SEW2871 - CAS 256414-75-2 - Calbiochem;Sphingosine-1-Phosphate₁ Receptor S1P1 Agonist, 5-(4-Phenyl-5-trifluoromethylthiophen-2-yl)-3-(3-trifluoromethylphenyl)-(1,2,4)-oxadiazole, SEW2871

CAS NO.：256414-75-2

Empirical Formula: C20H10F6N2OS

Molecular Weight: 440.36

MDL number: MFCD00096600

PRODUCT Properties

• Melting point: 94.5-95.3 °C
• Boiling point: 490.3±55.0 °C(Predicted)
• Density: 1.415±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: 17 mg/mL
• form: solid
• pka: -3.48±0.43(Predicted)
• color: white
• InChI: 1S/C20H10F6N2OS/c21-19(22,23)13-8-4-7-12(9-13)17-27-18(29-28-17)15-10-14(11-5-2-1-3-6-11)16(30-15)20(24,25)26/h1-10H
• InChIKey: OYMNPJXKQVTQTR-UHFFFAOYSA-N
• SMILES: FC(F)(F)c1cccc(c1)-c2noc(n2)-c3cc(-c4ccccc4)c(s3)C(F)(F)F

Description and Uses

Sphingosine-1-phosphate receptor 1 (S1P₁) is one of five high affinity G protein-coupled S1P receptors which mediate a variety of effects including lymphocyte recirculation in the blood. Non-selective S1P receptor agonists, such as FTY720, produce clinical immunosuppression useful for preventing transplant rejection and treating autoimmune diseases. However, they also cause bradycardia by activating S1P₃, the receptor responsible for regulation of heart rate. SEW2871 is a selective S1P₁ receptor agonist in both human and mouse that is not active at the S1P_2-5 receptors. SEW2871, therefore, suppresses the immune response by decreasing the number of lymphocytes circulating in blood without causing bradycardia.

SEW2871 was used to mimic the effects of sphingosine-1 phosphate in HUVECs to study the innate immunity rendered by long pentraxin 3.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H300
• Precautionary statements: P264-P270-P301+P310-P321-P330-P405-P501
• PPE: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• Hazard Codes: T
• Risk Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• HS Code: 2934999090
• Storage Class: 6.1C - Combustible acute toxic Cat.3; toxic compounds or compounds which causing chronic effects