Sertindole , 95% , 106516-24-9

Synonym(s):
1-[2-[4-[5-Chloro-1-(4-fluorophenyl)-1h-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinone

CAS NO.：106516-24-9

Empirical Formula: C24H26ClFN4O

Molecular Weight: 440.94

MDL number: MFCD00867749

PRODUCT Properties

• Melting point: 95-100°C
• Boiling point: 592.1±50.0 °C(Predicted)
• Density: 1.36
• storage temp.: Sealed in dry,2-8°C
• solubility: DMSO: >10mg/mL
• pka: 14.53±0.20(Predicted)
• form: solid
• color: off-white
• Merck: 14,8466
• InChI: InChI=1S/C24H26ClFN4O/c25-18-1-6-23-21(15-18)22(16-30(23)20-4-2-19(26)3-5-20)17-7-10-28(11-8-17)13-14-29-12-9-27-24(29)31/h1-6,15-17H,7-14H2,(H,27,31)
• InChIKey: GZKLJWGUPQBVJQ-UHFFFAOYSA-N
• SMILES: C1(=O)N(CCN2CCC(C3C4=C(N(C5=CC=C(F)C=C5)C=3)C=CC(Cl)=C4)CC2)CCN1

Description and Uses

Serdolect was launched in the UK for acute and chronic schizophrenia and schizoaffective psychoses. It is synthetically available in three steps from 5chloro-l- (4-fluorophenyl)-l H-indole. Sertindole is selective for the limbic areas of the brain and has a high affinity for the serotinin 5-HT₂ receptor where it behaves as an antagonist. It has weak affinity for the α₁-adrenergic receptor and no affinity for dopamine D₂ receptors. It is as effective as haloperidol but without the extrapyramidal symptoms. This may be a consequence of the fact that it expresses the c-fos protein in a manner different for haloperidol but similar to clozapine. It is non-sedating, long lasting (several days after a single dose) and has an atypical mode of action.

antipsychotic;Dopamine D2/Serotonin 5-HT2 receptor antagonist

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335-H413
• Precautionary statements: P261-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• RTECS: NJ0621100
• HS Code: 2933.99.6100