<small>L</small>-Kynurenine Hydrate , >98.0%(T) , 2922-83-0

Synonym(s):
β-Anthraniloyl-L-alanine;L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid

CAS NO.：2922-83-0

Empirical Formula: C10H12N2O3

Molecular Weight: 208.21

MDL number: MFCD00069912

PRODUCT Properties

• Melting point: 219 °C
• Boiling point: 466.6±45.0 °C(Predicted)
• Density: 1.343±0.06 g/cm3(Predicted)
• refractive index: -33 ° (C=0.4, H2O)
• storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• solubility: Soluble in DMSO (up to 2 mg/ml) or in Water (up to 2 mg/ml).
• form: crystalline
• pka: 2.21±0.23(Predicted)
• color: light yellow
• optical activity: -30.525 (H2O)
• Merck: 14,5328
• Stability: Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
• InChI: InChI=1/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/s3
• InChIKey: YGPSJZOEDVAXAB-QMMMGPOBSA-N
• SMILES: C1(C=CC=CC=1N)C(=O)C[C@H](N)C(=O)O |&1:10,r|
• CAS DataBase Reference: 2922-83-0(CAS DataBase Reference)

Description and Uses

Kynurenine (2922-83-0) is a tryptophan catabolite.1?Endogenous tumor-promoting ligand of the human aryl hydrocarbon receptor (AhR). Constitutively generated by human tumor cells via the action of the tryptophan degrading enzyme, tryptophan-2,3-dioxygenase (TDO). Kynurenine suppresses antitumor immune responses and promotes tumor cell survival and motility.2

L-Kynurenine has been used as a standard for indoleamine-2,3-dioxygenase (IDO) assay. It has also been used as a standard to extract and quantify kynurenine from cultured cells and media.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P280-P301+P312-P302+P352-P305+P351+P338
• WGK Germany: 3
• RTECS: CY9049700
• HS Code: 2922500090