<small>L</small>-Phenylephrine , >98.0%(HPLC) , 59-42-7
Synonym(s):
L -Phenylephrine
CAS NO.：59-42-7
Empirical Formula: C9H13NO2
Molecular Weight: 167.21
MDL number: MFCD00044749
EINECS: 200-424-8
| Pack Size | Price | Stock | Quantity |
| 1G | RMB92.80 | In Stock |
|
| 5G | RMB280.00 | In Stock |
|
| 25G | RMB888.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 171°C |
| Boiling point: | 295.79°C (rough estimate) |
| Density | 1.1222 (rough estimate) |
| refractive index | -55.5 ° (C=5, 1mol/L HCl) |
| storage temp. | -20°C Freezer, Under inert atmosphere |
| solubility | Slightly soluble in water, sparingly soluble in methanol, slightly soluble in ethanol (96 per cent). It dissolves in dilute mineral acids and in dilute solutions of alkali hydroxides. |
| pka | pKa 8.9 (Uncertain) |
| form | Solid |
| color | White to Off-White |
| InChI | InChI=1/C9H13NO2/c1-10-6-9(12)7-3-2-4-8(11)5-7/h2-5,9-12H,6H2,1H3/t9-/s3 |
| InChIKey | SONNWYBIRXJNDC-DJEYLCQNNA-N |
| SMILES | [C@H](C1C=CC=C(O)C=1)(O)CNC |&1:0,r| |
| CAS DataBase Reference | 59-42-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzenemethanol, 3-hydroxy-«alpha»-[(methylamino)methyl]-, (r)-(59-42-7) |
Description and Uses
This synthetic drug has both chemical and pharmacological similarities to norepinephrine. A characteristic quality of phenylephrine is the distinctly expressed selectivity to α- adrenoreceptors, especially α1-adrenoreceptors. Although phenylephrine increases the contractibility of blood vessels, in practical terms it is not considered a cardiostimulant.
L-Phenylephrine is an adrenergic α1A receptor agonist (Ki = 1.4 μM) that demonstrates selectivity against the α1B and α1C receptor subtypes (Kis = 23.9 and 47.8 μM, respectively). By stimulating adrenergic α1 receptors, L-phenylephrine can induce aortic smooth muscle contractions, although reported relative affinity and potency values in rabbit are 5-fold weaker compared to that of L-norepinephrine. This compound is frequently used to precontract smooth muscle in preparations designed to study the properties of various vasodilator agents. Because L-phenylephrine acts on adrenergic α1 receptors in the arterioles of the nasal mucosa to produce constriction, it has been examined clinically as an oral decongestant.
Safety
| Symbol(GHS) |   GHS05,GHS07 |
| Signal word | Danger |
| Hazard statements | H302-H315-H318-H335 |
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38-41-37/38 |
| Safety Statements | 26-36-45-39 |
| RTECS | DO7175000 |
| HS Code | 2922.19.7000 |
| Hazardous Substances Data | 59-42-7(Hazardous Substances Data) |
| Toxicity | LD50 oral in rat: 350mg/kg |
