(3S)-3-{4-[(2-chloro-5-iodophenyl)methyl]phenoxy}oxolane , 97% , 915095-94-2

CAS NO.：915095-94-2

Empirical Formula: C17H16ClIO2

Molecular Weight: 414.67

MDL number: MFCD28098707

EINECS: 619-599-0

PRODUCT Properties

• Boiling point: 476.0±45.0 °C(Predicted)
• Density: 1.578±0.06 g/cm3 (20 ºC 760 Torr)
• storage temp.: 2-8°C(protect from light)
• solubility: DMSO, Methanol (Slightly, Sonicated)
• form: Solid
• color: White to Off-White
• InChI: InChI=1S/C17H16ClIO2/c18-17-6-3-14(19)10-13(17)9-12-1-4-15(5-2-12)21-16-7-8-20-11-16/h1-6,10,16H,7-9,11H2/t16-/m0/s1
• InChIKey: YLUHNGIWRCCQMQ-INIZCTEOSA-N
• SMILES: O1CC[C@H](OC2=CC=C(CC3=CC(I)=CC=C3Cl)C=C2)C1
• CAS DataBase Reference: 915095-94-2

Description and Uses

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran is a pharmaceutical intermediate compound that is used in the preparation of empagliflozin. Empagliflozin is an inhibitor of sodium-glucose co-transporter protein-2 (SGLT2), which is used in the treatment of type 2 diabetes.

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran (compound 2d), a halogenated Phenstatin analog, is a microtubule destabilizing agent. (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran shows anticancer activities[1].

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338