HA1100hydrochloride(Hydroxyfasudil) , 10mMinDMSO , 155558-32-0

Synonym(s):
1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine hydrochloride hydrate;Hydroxyfasudil - CAS 155558-32-0 - Calbiochem;ROCK Inhibitor XIV, 1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine, HCl, HA1100

CAS NO.：155558-32-0

Empirical Formula: C14H18ClN3O3S

Molecular Weight: 343.829

MDL number: MFCD06411567

PRODUCT Properties

• Melting point: >250 (dec.)
• storage temp.: Inert atmosphere,2-8°C
• solubility: H2O: >5mg/mL
• form: solid
• color: white
• Water Solubility: Soluble in water (20mM)
• InChI: InChI=1S/C14H17N3O3S.ClH/c18-14-12-3-1-4-13(11(12)5-7-16-14)21(19,20)17-9-2-6-15-8-10-17;/h1,3-5,7,15H,2,6,8-10H2,(H,16,18);1H
• InChIKey: XWWFOUVDVJGNNG-UHFFFAOYSA-N
• SMILES: c1c(S(=O)(=O)N2CCNCCC2)c2ccnc(O)c2cc1.Cl

Description and Uses

A metabolite of Fasudil. A cell-permeable, hydroxylated metabolite of HA 1077 that displays anti-anginal properties. Reported to inhibit the Rho kinase-mediated (ROCK) contraction both in vitro and in vivo.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312-P501
• Hazard Codes: Xn
• Risk Statements: 22
• WGK Germany: 3