A7634758
Nα-p-Tosyl-L-argininemethylesterhydrochloride , 10mMinDMSO , 1784-03-8
Synonym(s):
Anaphase-Promoting Complex Inhibitor, TAME - CAS 1784-03-8 - Calbiochem;TAME hydrochloride;TAME hydrochloride, APC/C Inhibitor I, APC/C-Cdc20 Interaction Inhibitor I, Cyclosome Inhibitor I
CAS NO.：1784-03-8
Empirical Formula: C14H23ClN4O4S
Molecular Weight: 378.875
MDL number: MFCD00012578
EINECS: 217-235-1
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB159.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 145-147(lit.) |
| alpha | -14 º (c=4, H2O) |
| refractive index | -14 ° (C=4, H2O) |
| storage temp. | -20°C |
| solubility | methanol: 50 mg/mL, clear, colorless |
| form | Fine Crystalline Powder |
| color | White |
| BRN | 3922357 |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months. |
| InChI | 1S/C14H22N4O4S.ClH/c1-10-5-7-11(8-6-10)23(20,21)18-12(13(19)22-2)4-3-9-17-14(15)16;/h5-8,12,18H,3-4,9H2,1-2H3,(H4,15,16,17);1H/t12-;/m0./s1 |
| InChIKey | JIQFFACVQXXHMY-YDALLXLXSA-N |
| SMILES | Cl.COC(=O)[C@H](CCCNC(N)=N)NS(=O)(=O)c1ccc(C)cc1 |
| CAS DataBase Reference | 1784-03-8(CAS DataBase Reference) |
Description and Uses
TAME (1784-03-8) binds to the ubiquitin ligase anaphase-promoting complex (APC) preventing its activation by Cdc20 and Cdh1 and resulting in mitotic arrest.1,2
enzyme inhibitor
Safety
| Symbol(GHS) |     GHS07,GHS08,GHS09,GHS02 |
| Signal word | Danger |
| Hazard statements | H319-H361-H371-H336-H304-H411-H224 |
| Precautionary statements | P501-P273-P260-P270-P202-P240-P210-P233-P201-P243-P241-P242-P271-P264-P280-P370+P378-P391-P331-P337+P313-P305+P351+P338-P308+P311-P303+P361+P353-P301+P310-P304+P340+P312-P403+P233-P403+P235-P405 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 22-24/25-37/39-26 |
| WGK Germany | 3 |
| F | 3-10 |
| HS Code | 29252900 |
| Storage Class | 11 - Combustible Solids |
