Metyrapone , 10mMinDMSO , 54-36-4

Synonym(s):
2-Methyl-1,2-di-3-pyridyl-1-propanone;Metyrapone;Su-4885

CAS NO.：54-36-4

Empirical Formula: C14H14N2O

Molecular Weight: 226.27

MDL number: MFCD00006397

EINECS: 200-206-2

PRODUCT Properties

• Melting point: 52-55 °C(lit.)
• Boiling point: 367.89°C (rough estimate)
• Density: 1.0852 (rough estimate)
• refractive index: 1.6419 (estimate)
• Flash point: >230 °F
• storage temp.: Inert atmosphere,Room Temperature
• solubility: H2O: soluble (sparingly)
• form: solid
• pka: 4.61±0.10(Predicted)
• color: White
• Merck: 13,6181
• BRN: 163023
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
• InChI: InChI=1S/C14H14N2O/c1-14(2,12-6-4-8-16-10-12)13(17)11-5-3-7-15-9-11/h3-10H,1-2H3
• InChIKey: FJLBFSROUSIWMA-UHFFFAOYSA-N
• SMILES: C(C1=CC=CN=C1)(=O)C(C)(C1=CC=CN=C1)C
• EPA Substance Registry System: Metyrapone (54-36-4)

Description and Uses

Metyrapone (54-36-4) inhibits cytochrome P450-mediated prostaglandin omega hydroxylation. Inhibits steroid 11β-hydroxylase thereby inhibiting cortisol biosynthesis.

Diagnostic aid (pituitary function);steroid 11?-hydroxylase inhibitor

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
• Hazard Codes: Xn
• Risk Statements: 22-36/37/38
• Safety Statements: 26
• WGK Germany: 3
• RTECS: UC3050000
• HS Code: 2933399090
• Hazardous Substances Data: 54-36-4(Hazardous Substances Data)
• Toxicity: A well-known inhibitor of monooxygenase reactions and can also, under some circumstances, stimulate metabolism of xenobiotics in vitro. In either case, the effect is non-competitive, in that the KM does not change whereas Vmax does, decreasing in the case of inhibition and increasing in the case of stimulation.