A7667412
Trimethyl orthoformate , 99.8%, no water grade , 149-73-5
Synonym(s):
Methyl orthoformate, Orthoformic acid trimethyl ester;TMOF;Trimethoxymethane;Trimethyl orthoformate
CAS NO.：149-73-5
Empirical Formula: C4H10O3
Molecular Weight: 106.12
MDL number: MFCD00008483
EINECS: 205-745-7
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | -53 °C |
| Boiling point: | 101-102 °C(lit.) |
| Density | 0.97 g/mL at 25 °C(lit.) |
| vapor density | 3.67 (vs air) |
| vapor pressure | 23.5 mm Hg ( 20 °C) |
| refractive index | n |
| Flash point: | 60 °F |
| storage temp. | Store below +30°C. |
| solubility | Miscible with ether, alcohol and benzene. |
| form | Liquid |
| color | Clear colorless |
| explosive limit | 1.4-44.6%(V) |
| Water Solubility | 10 g/L (hydrolysis) |
| Sensitive | Moisture Sensitive |
| Merck | 14,6884 |
| BRN | 969215 |
| InChIKey | PYOKUURKVVELLB-UHFFFAOYSA-N |
| LogP | -0.03-0.09 at 20℃ |
| CAS DataBase Reference | 149-73-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Methane, trimethoxy-(149-73-5) |
| EPA Substance Registry System | Trimethoxymethane (149-73-5) |
Description and Uses
Trimethyl orthoformate is an effective solvent for thallium(III) nitrate-mediated oxidations. It undergoes acid catalyzed reaction with 6-(N-D-ribitylanilino) uracils to form 8-demethyl-8-hydroxy-5-deazariboflavins.
Trimethyl Orthoformate is the most simple orthoester. Used in organic synthesis as a reagent for introducing a protecting group for aldehydes and in the creation of methoxymethylene groups and heterocyclic ring systems.
Safety
| Symbol(GHS) |   GHS02,GHS07 |
| Signal word | Danger |
| Hazard statements | H225-H319 |
| Precautionary statements | P210-P233-P240-P241-P242-P305+P351+P338 |
| Hazard Codes | F,Xi |
| Risk Statements | 11-36 |
| Safety Statements | 9-16-26-29 |
| RIDADR | UN 3272 3/PG 2 |
| WGK Germany | 1 |
| RTECS | RM6650000 |
| Autoignition Temperature | 255 °C |
| TSCA | Yes |
| HazardClass | 3 |
| PackingGroup | II |
| HS Code | 29159080 |
| Hazardous Substances Data | 149-73-5(Hazardous Substances Data) |
| Toxicity | LD50 orally in Rabbit: 3130 mg/kg |
| Limited Quantities | 1.0 L (0.3 gallon) (liquid) |
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) |
