A7682758
EPZ015666 , 10mMinDMSO , 1616391-65-1
Synonym(s):
(S)-N-(3-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide;GSK3235025;YQ36286
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB559.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 124-131°C |
| Boiling point: | 686.4±55.0 °C(Predicted) |
| Density | 1.331±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 20 mg/ml) |
| pka | 12.40±0.46(Predicted) |
| form | powder |
| color | white to beige |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| InChIKey | ZKXZLIFRWWKZRY-KRWDZBQOSA-N |
| SMILES | C1=NC(NC2COC2)=CC(C(NC[C@H](O)CN2CCC3=C(C2)C=CC=C3)=O)=N1 |
| CAS DataBase Reference | 1616391-65-1 |
Description and Uses
EPZ015666 (1616391-65-1) is a selective and potent (IC50= 22nM) inhibitor of arginine methyltransferase 5 (PRMT5).1,2PRMT5 inhibition with EPZ015666 potently suppressedin vivoglioblastoma tumors3and significantly inhibited the growth of multiple myeloma cell lines4.
EPZ015666 is a potent, orally bioavailable inhibitor of Protein arginine methyltransferase 5 (PRMT5). It acts by blocking the association of PRMT5 with methylosome protein 50.
Safety
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
