Nα-p-Tosyl-L-arginine methyl ester hydrochloride , 98% , 1784-03-8

Synonym(s):
Anaphase-Promoting Complex Inhibitor, TAME - CAS 1784-03-8 - Calbiochem;TAME hydrochloride;TAME hydrochloride, APC/C Inhibitor I, APC/C-Cdc20 Interaction Inhibitor I, Cyclosome Inhibitor I

CAS NO.：1784-03-8

Empirical Formula: C14H23ClN4O4S

Molecular Weight: 378.875

MDL number: MFCD00012578

EINECS: 217-235-1

PRODUCT Properties

• Melting point: 145-147(lit.)
• alpha: -14 º (c=4, H2O)
• refractive index: -14 ° (C=4, H2O)
• storage temp.: -20°C
• solubility: methanol: 50 mg/mL, clear, colorless
• form: Fine Crystalline Powder
• color: White
• BRN: 3922357
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
• InChI: 1S/C14H22N4O4S.ClH/c1-10-5-7-11(8-6-10)23(20,21)18-12(13(19)22-2)4-3-9-17-14(15)16;/h5-8,12,18H,3-4,9H2,1-2H3,(H4,15,16,17);1H/t12-;/m0./s1
• InChIKey: JIQFFACVQXXHMY-YDALLXLXSA-N
• SMILES: Cl.COC(=O)[C@H](CCCNC(N)=N)NS(=O)(=O)c1ccc(C)cc1
• CAS DataBase Reference: 1784-03-8(CAS DataBase Reference)

Description and Uses

TAME (1784-03-8) binds to the ubiquitin ligase anaphase-promoting complex (APC) preventing its activation by Cdc20 and Cdh1 and resulting in mitotic arrest.1,2

enzyme inhibitor

Safety

• Symbol(GHS): GHS07,GHS08,GHS09,GHS02
• Signal word: Danger
• Hazard statements: H319-H361-H371-H336-H304-H411-H224
• Precautionary statements: P501-P273-P260-P270-P202-P240-P210-P233-P201-P243-P241-P242-P271-P264-P280-P370+P378-P391-P331-P337+P313-P305+P351+P338-P308+P311-P303+P361+P353-P301+P310-P304+P340+P312-P403+P233-P403+P235-P405
• PPE: Eyeshields, Gloves, type N95 (US)
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 22-24/25-37/39-26
• WGK Germany: 3
• F: 3-10
• HS Code: 29252900
• Storage Class: 11 - Combustible Solids