p-Toluenesulfonyl isocyanate , 96% , 4083-64-1

Synonym(s):
p-Tosyl isocyanate;Tosyl isocyanate;TsNCO

CAS NO.：4083-64-1

Empirical Formula: C8H7NO3S

Molecular Weight: 197.21

MDL number: MFCD00002030

EINECS: 223-810-8

PRODUCT Properties

• Melting point: 5°C
• Boiling point: 144 °C10 mm Hg(lit.)
• Density: 1.291 g/mL at 25 °C(lit.)
• vapor pressure: 1 mm Hg ( 100 °C)
• refractive index: n20/D 1.534(lit.)
• Flash point: >230 °F
• storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
• form: Liquid
• color: Clear colorless to yellow
• Specific Gravity: 1.291.291
• Odor: acrid odor
• Water Solubility: reacts
• Sensitive: Moisture Sensitive
• BRN: 391287
• InChIKey: VLJQDHDVZJXNQL-UHFFFAOYSA-N
• LogP: 0.6 at 30℃
• CAS DataBase Reference: 4083-64-1(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methylbenzenesulfonyl isocyanate(4083-64-1)
• EPA Substance Registry System: Benzenesulfonyl isocyanate, 4-methyl- (4083-64-1)

Description and Uses

It is a reagent used to prepare acetylated syn-1,2-diols,oxazolidin-2-ones, 2,3-diamino acids, and N-tosylcarbonamides. -Toluenesulfonyl isocyanate has been used as derivatization reagent in determination of 3-α-hydroxy tibolone in human plasma by LC-MS/MS. It is also employed in the derivatization reagent in simultaneous quantitative analysis of diethylene glycol and propylene glycol in pharmaceutical products by HPLC and as reagent in the preparation of acetylated syn-1,2-diols, oxazolidin-2-ones, 2,3-diamino acids and N-tosylcarbonamides.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Danger
• Hazard statements: H315-H319-H334-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xn
• Risk Statements: 14-36/37/38-42
• Safety Statements: 26-28-30-28A
• RIDADR: UN 2206 6.1/PG 3
• WGK Germany: 1
• RTECS: DB9032000
• F: 10
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: III
• HS Code: 29309090