α-Ketoglutaricacid , 10mMinDMSO , 328-50-7
Synonym(s):
2-Ketoglutaric acid;2-Oxoglutaric acid;2-Oxopentanedioic acid;alpha-Ketoglutarate;alpha-Ketoglutaric acid
CAS NO.：328-50-7
Empirical Formula: C5H6O5
Molecular Weight: 146.1
MDL number: MFCD00004165
EINECS: 206-330-3
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB159.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 113-115 °C |
| Boiling point: | 185.67°C (rough estimate) |
| Density | 1.2821 (rough estimate) |
| bulk density | 800kg/m3 |
| vapor pressure | 0.01Pa at 25℃ |
| refractive index | 1.3920 (estimate) |
| FEMA | 3891 | 2-OXOPENTANEDIOIC ACID |
| storage temp. | 2-8°C |
| solubility | H2O: soluble0.1g/mL, clear, colorless |
| form | Crystalline Powder |
| pka | 2.47(at 25℃) |
| color | White to slightly yellow |
| PH | 3.09(1 mM solution);2.36(10 mM solution);1.77(100 mM solution) |
| Odor | Odorless |
| Water Solubility | Soluble in water, methanol and dimethyl sulfoxide. |
| JECFA Number | 634 |
| Merck | 14,5303 |
| BRN | 1705689 |
| Cosmetics Ingredients Functions | DEODORANT |
| InChI | 1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10) |
| InChIKey | KPGXRSRHYNQIFN-UHFFFAOYSA-N |
| SMILES | OC(=O)CCC(=O)C(O)=O |
| LogP | -2.08 at 25℃ |
| CAS DataBase Reference | 328-50-7(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Oxopentanedioic acid(328-50-7) |
| EPA Substance Registry System | Pentanedioic acid, 2-oxo- (328-50-7) |
Description and Uses
2-Ketoglutaric acid also known as α-Ketoglutaric acid (AKG) is a chemical found in the body. It is a ketone derivative of the organic compound glutaric acid. It is important for the proper metabolism of all essential amino acids and the transfer of cellular energy in the citric acid or Krebs cycle. In combination with L-glutamate, AKG can reduce levels of ammonia formed in the brain, muscles, and kidneys, as well as help balance the body’s nitrogen chemistry and prevent nitrogen excess in body tissues and fluids.
α-Ketoglutaric acid is used for kidney disease; intestinal and stomach disorders, including bacterial infections; liver problems; cataracts; and recurring yeast infections. It is also used for improving the way kidney patients receiving hemodialysis treatments process protein.
2-Ketoglutaric acid has a wide range of applications in the animal feed, food, pharmaceutical and fine chemistry industries. It is used as an intermediate in the kreb's cycle catalyzed by glutamate dehydrogenase enzyme on glutamate. It is also used in dietary supplements to improve protein synthesis.
Safety
| Symbol(GHS) |  GHS05 |
| Signal word | Danger |
| Hazard statements | H318 |
| Precautionary statements | P280-P305+P351+P338+P310 |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi,T |
| Risk Statements | 37/38-41-36/37/38-23/24/25 |
| Safety Statements | 26-39-45-36/37/39 |
| WGK Germany | 3 |
| TSCA | TSCA listed |
| HS Code | 29183000 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Dam. 1 |
