KN-93 , 10mMinDMSO , 139298-40-1

Synonym(s):
2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine);InSolution KN-93 - CAS 139298-40-1 - Calbiochem;N-[2-[[[3-(4′-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4′-methoxybenzenesulfonamide phosphate salt;N-[2-[N-(4-Chlorocinnamyl)-N-methylaminomethyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate salt

CAS NO.：139298-40-1

Empirical Formula: C26H29ClN2O4S

Molecular Weight: 501.04

MDL number: MFCD00236424

PRODUCT Properties

• Density: 1.288
• storage temp.: 2-8°C
• solubility: DMSO: 1 mg/mL
• form: Off-white solid
• color: white
• biological source: synthetic (organic)
• Water Solubility: water: 5mg/mL
• InChIKey: LLLQTDSSHZREGW-AATRIKPKSA-N
• CAS DataBase Reference: 139298-40-1(CAS DataBase Reference)

Description and Uses

KN-93 is a selective inhibitor of Ca²⁺/calmodulin-dependent kinase type II (CaMKII), competitively blocking CaM binding to the kinase (K_i = 370 nM). It does not affect the activities of PKA, PKC, MLCK, or Ca²⁺-phosphodiesterase. It inhibits histamine-induced aminopyrine uptake in parietal cells (IC₅₀ = 300 nM). More recently, KN-93 has been used to implicate roles for CaMKII in Ca²⁺-induced Ca²⁺ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca²⁺-dependent activation of HIF-1α in colon cancer cells.

KN-93 has been used:

• as an inhibitor to block αCaMKII (Ca²⁺/calmodulin-dependent protein kinase IIα)
• as CaMKII inhibitor to pre-treat hippocampal slices
• to treat the cells, to alter the cytoskeleton (CSK) structure and function during the experiment

Safety

• Hazard Codes: Xn
• Risk Statements: 20/21/22
• Safety Statements: 22-24/25-36/37
• WGK Germany: 3
• HS Code: 29299000