A7744858
LarotrectinibFor , 10mMinDMSO , 1223403-58-4
CAS NO.：1223403-58-4
Empirical Formula: C21H22F2N6O2
Molecular Weight: 428.44
MDL number: MFCD28902192
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB205.60 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Density | 1.55±0.1 g/cm3(Predicted) |
| storage temp. | RT |
| solubility | Soluble in DMSO (up to 5 mg/ml). |
| form | solid |
| pka | 8.41±0.40(Predicted) |
| color | Yellow |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
Description and Uses
LOXO-101 is an inhibitor of the tropomyosin-related kinases TrkA, TrkB, and TrkC (IC50s = 2-20 nM). It is selective for TrkA, -B, and -C over a panel of 226 kinases at 1 μM. LOXO-101 inhibits the growth of CUTO-3.29, KM12, and MO-91 patient-derived cancer cell lines (IC50s = <100, <10, and <10 nM, respectively). In vivo, LOXO-101 (60 and 200 mg/kg) reduces tumor growth in a KM12 mouse xenograft model.
Larotrectinib is a TRK Inhibitor (Tyrosine kinase inhibitor).
