3-Isobutyl-1-methylxanthine , 10mMinDMSO , 28822-58-4
Synonym(s):
1-Methyl-3-isobutylxanthine;3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione;3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione;3-Isobutyl-1-methylxanthine - CAS 28822-58-4 - Calbiochem;IBMX
CAS NO.：28822-58-4
Empirical Formula: C10H14N4O2
Molecular Weight: 222.24
MDL number: MFCD00005584
EINECS: 249-259-3
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB159.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 200-201 °C(lit.) |
| Boiling point: | 363.42°C (rough estimate) |
| Density | 1.2042 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| storage temp. | -20°C |
| solubility | DMSO: 1 M with gentle warming |
| form | powder |
| pka | 8.61±0.70(Predicted) |
| color | off-white |
| BRN | 247859 |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| InChI | InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12) |
| InChIKey | APIXJSLKIYYUKG-UHFFFAOYSA-N |
| SMILES | N1C2=C(N(CC(C)C)C(=O)N(C)C2=O)NC=1 |
| CAS DataBase Reference | 28822-58-4(CAS DataBase Reference) |
Description and Uses
IBMX (28822-58-4) is a pan-specific inhibitor of phosphodiesterases (IC50=2-50 μM). Inhibition of PDEs leads to increased concentration of intracellular cAMP which activates PKA.2?IBMX does not inhibit PDE8 or PDE9.3?Weak adenosine receptor antagonist.4
3-Isobutyl-1-methylxanthine is used in inhibition of phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50 = 1.3 uM). Also inhibits ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Inhibits the growth of carcinoma cells both in vivo and in vitro in mice.
