TAK-242 , ≥98% , 243984-11-4

Synonym(s):
Ethyl-(6 R)-6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate;Ethyl-(6R)-6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate

CAS NO.：243984-11-4

Empirical Formula: C15H17ClFNO4S

Molecular Weight: 361.82

MDL number: MFCD11046362

PRODUCT Properties

• Melting point: 68-69℃
• Boiling point: 462.0±55.0 °C(Predicted)
• Density: 1.39
• storage temp.: Sealed in dry,Room Temperature
• solubility: insoluble in H2O; ≥100.6 mg/mL in EtOH; ≥18.09 mg/mL in DMSO
• form: Solid
• pka: 7.08±0.40(Predicted)
• color: Off-white to yellow
• InChI: InChI=1S/C15H17ClFNO4S/c1-2-22-15(19)11-5-3-4-6-14(11)23(20,21)18-13-8-7-10(17)9-12(13)16/h5,7-9,14,18H,2-4,6H2,1H3/t14-/m1/s1
• InChIKey: LEEIJTHMHDMWLJ-CQSZACIVSA-N
• SMILES: C1(C(OCC)=O)[C@H](S(NC2=CC=C(F)C=C2Cl)(=O)=O)CCCC=1

Description and Uses

Resatorvid is a novel selective Toll-like receptor 4 signal transduction inhibitor. Resatorvid inhibits various kinds of inflammatory mediators such as nitric oxide (NO), tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-6, IL-10, macrophage inhibitory protein (MIP)-2 and prostaglandin E2 from lipopolysaccharide (LPS)-stimulated macrophages.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• HS Code: 2935909099