A2316012
Celastrol , 98% , 34157-83-0
Synonym(s):
10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-picene-2-carboxylic acid;Celastrol, Celastrus scandens - CAS 34157-83-0 - Calbiochem;Tripterin;Tripterin, 3-Hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic Acid, Proteasome Inhibitor XIX
CAS NO.：34157-83-0
Empirical Formula: C29H38O4
Molecular Weight: 450.61
MDL number: MFCD03424073
EINECS: 636-472-5
| Pack Size | Price | Stock | Quantity |
| 10MG | RMB194.40 | In Stock |
|
| 50MG | RMB718.40 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 219-230°C |
| Boiling point: | 645.7±55.0 °C(Predicted) |
| Density | 1.2 |
| storage temp. | -20°C |
| solubility | DMSO: >10mg/mL |
| pka | 4.78±0.70(Predicted) |
| form | solid |
| color | red |
| λmax | 424nm(MeOH)(lit.) |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| InChIKey | KQJSQWZMSAGSHN-JJWQIEBTSA-N |
| SMILES | [C@]12(C)CC[C@@]3(C)CC[C@@](C)(C(=O)O)C[C@@]3([H])[C@]1(C)CC[C@@]1(C)C3=CC(C(O)=C(C)C3=CC=C21)=O |&1:0,4,8,14,16,20,r| |
| LogP | 7.080 (est) |
| CAS DataBase Reference | 34157-83-0(CAS DataBase Reference) |
Description and Uses
Celastrol (34157-83-0) displays potent antioxidant and anti-inflammatory activity. Inhibits NFkB (IC50=270 nM). It induces heat shock response and cytoprotection in various cells. Inhibits 20S proteasome chymotrypsin activity (IC50=2.5 mM). Induces autophagy by targeting AR/miR-101 in prostate cancer cells.4 Induces UPR-dependent cell death in cancer cells.5 Cell permeable.
antineoplastic, NO synthesis inhibitor, chaperone stimulant
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301+P310 |
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45-24/25 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | 2 |
| RTECS | YJ7900000 |
| HS Code | 29189900 |
| Storage Class | 11 - Combustible Solids |
