A-769662 , ≥98% , 844499-71-4

CAS NO.：844499-71-4

Empirical Formula: C20H12N2O3S

Molecular Weight: 360.39

MDL number: MFCD11977269

PRODUCT Properties

• Melting point: 263 - 266oC
• Boiling point: 630.1±55.0 °C(Predicted)
• Density: 1.56
• Flash point: 334.9℃
• storage temp.: Keep in dark place,Sealed in dry,Room Temperature
• solubility: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 5 mg/ml),
• form: solid
• pka: 4.50±1.00(Predicted)
• color: Beige
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
• InChI: 1S/C20H12N2O3S/c21-9-14-18(24)17-15(10-26-20(17)22-19(14)25)12-7-5-11(6-8-12)13-3-1-2-4-16(13)23/h1-8,10,23H,(H2,22,24,25)
• InChIKey: CTESJDQKVOEUOY-UHFFFAOYSA-N
• SMILES: [s]1c2[nH][c](c(c(c2c(c1)c3ccc(cc3)c4c(cccc4)O)O)C#N)=O

Description and Uses

A-769662 is a small molecule thienopyridone that activates AMPK directly in cell-free assays (EC₅₀ = 116 nM) and intact cells by allosterically activating AMPK and inhibiting its dephosphorylation on Thr¹⁷². A-769662 specifically activates β1 subunit-containing AMPK heterotrimers, and its effects are independent of kinases upstream of AMPK. A-769662 has been used to stimulate CYP450-mediated fatty acid oxidation, inhibit adipocyte differentiation, explore glucose uptake in skeletal muscle, and promote endothelial cell survival during metabolic stress.

A 769662 is an AMP-activated protein kinase (AMPK) activiator. A 769662 selectively activates cardiac AMPK heterotrimeric complexes contg. α2/β1-subunits.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H312-H332-H319
• Precautionary statements: P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P280-P302+P352-P312-P322-P363-P501-P261-P271-P304+P340-P312-P264-P280-P305+P351+P338-P337+P313P
• Safety Statements: 24/25
• WGK Germany: WGK 3
• HS Code: 29333990
• Storage Class: 11 - Combustible Solids