Galeterone , ≥98% , 851983-85-2

Synonym(s):
3β-Hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene;TOK-001;VN/124-1;VN-124-1

CAS NO.：851983-85-2

Empirical Formula: C26H32N2O

Molecular Weight: 388.55

MDL number:

EINECS: 806-537-4

Pack Size	Price	Stock	Quantity
5MG	RMB447.20	In Stock
25MG	RMB823.20	In Stock
100MG	RMB1632.80	In Stock
others			Enquire

Update time: 2022-07-08

PRODUCT Properties

Melting point:	189-190℃
Boiling point:	564.5±60.0 °C(Predicted)
Density	1.28
storage temp.	-20°C Freezer
solubility	Chloroform (Slightly), Ethyl Aceatae (Slightly, Heated)
pka	14.71±0.70(Predicted)
form	Solid
color	White to Off-White
InChIKey	PAFKTGFSEFKSQG-MRFMOSGMNA-N
SMILES	C1C[C@]2(C)C3CC[C@]4(C)C([n]5cnc6ccccc56)=CCC4C3CC=C2C[C@H]1O \|&1:2,7,27,r\|

Description and Uses

Galeterone (TOK-001) is a small molecule oral drug that disrupts AR signaling by a novel triple mechanism: it potently and selectively inhibits CYP17 lyase, potently antagonizes AR and decreases AR protein levels (wild-type and mutant), leading to antitumor activity. Galeterone has shown significant anti-tumour activity with a well-tolerated safety profile in patients with CRPC in phase I and II clinical studies.

Galeterone is an androgen receptor antagonist and CYP17A1 enzyme inhibitor. It has been used in trials studying the treatment of Prostate Cancer.