A7820212
Tranilast , ≥98%(HPLC) , 53902-12-8
Synonym(s):
3,4-DAA;N-(3?,4?-Dimethoxycinnamoyl)anthranilic Acid;N-(3,4-Dimethoxycinnamoyl)anthranilic acid;Rizaben;2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino] benzoic acid
| Pack Size | Price | Stock | Quantity |
| 250mg | RMB28.00 | In Stock |
|
| 1G | RMB45.60 | In Stock |
|
| 5G | RMB134.40 | In Stock |
|
| 25g | RMB571.20 | In Stock |
|
| 100g | RMB2063.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 166.2-168.2 °C (lit.) |
| Boiling point: | 465.23°C (rough estimate) |
| Density | 1.3185 (rough estimate) |
| refractive index | 1.5100 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO: 18 mg/mL |
| form | powder |
| pka | 3.47±0.36(Predicted) |
| color | white to beige |
| Merck | 14,9570 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| InChI | 1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+ |
| InChIKey | NZHGWWWHIYHZNX-CSKARUKUSA-N |
| SMILES | COc1ccc(\C=C\C(=O)Nc2ccccc2C(O)=O)cc1OC |
| CAS DataBase Reference | 53902-12-8(CAS DataBase Reference) |
Description and Uses
Tranilast (53902-12-8) is an anti-allergy agent (inhibitor of mast cell degranulation) that has been shown to have potent immunomodulatory effects via inhibition of endotoxin induced: PGE2, IC50 = 1-20 μM; TXB2, IC50 = 10-50 μM; TGFβ1, IC50 = 100-200 μM; IL-8, IC50 = 100 μM .1-3 Tranilast also displays anti-angiogenic properties.4,5
coronary vasodilator
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P501 |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | DG8731000 |
| HS Code | 2924.29.6250 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
| Toxicity | LD50 in male, female mice, male, female rats (mg/kg): 780, 680, 1600, 1100 orally; 410, 385, 405, 395 i.p.; 2630, 2820, 3630, 3060 s.c. (Nakazawa, p 385) |
