Trichostatin A , ≥98% , 58880-19-6

Synonym(s):
[R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide;4,6-Dimethyl-7-[ p-dimethylaminophenyl]-7-oxahepta-2,4-dienohydroxamic Acid, TSA, HDAC Inhibitor IX;Trichostatin A;Trichostatin A, Streptomyces sp. - CAS 58880-19-6 - Calbiochem;TSA

CAS NO.：58880-19-6

Empirical Formula: C17H22N2O3

Molecular Weight: 302.37

MDL number: MFCD03848392

EINECS: 611-758-2

PRODUCT Properties

• Melting point: 140-143℃
• alpha: D20.5 +62.8° ±1.1° (c = 1.007 in ethanol)
• Density: 1.139
• refractive index: 136 ° (C=0.3, MeOH)
• storage temp.: -20°C
• solubility: ethanol: 1 mg/mL
• pka: 8.93±0.23(Predicted)
• form: Off-white lyophilized solid
• color: Tan
• biological source: Streptomyces sp.
• Merck: 14,9649
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
• InChIKey: ZWGICMNKJBUOHG-RCXLNATQSA-N

Description and Uses

Trichostatin A (58880-19-6) is a potent and selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM). Induces reversion of ras transformed cells to normal morphology. Trichostatin A induces dedifferentiation of primordial germ cells into embryonic germ cells. Cell permeable and active in vivo.

Trichostatin A, ready-made solution has been used:

• as a histone deacetylase inhibitor to study its effect on transcriptome changes by stem cell testing
• to inhibit histone deacetylase (HDAC) class I, II, or III in primary pituitary cell cultures and to investigate insulin control of endogenous human growth hormone gene (hGH)
• to treat cells for the HDAC inhibition experiments

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302+H312+H332-H315-H317-H319-H335
• Precautionary statements: P261-P280-P305+P351+P338
• Hazard Codes: Xn,Xi
• Risk Statements: 20/21/22-36/37/38-43
• Safety Statements: 26-36
• RIDADR: NA 1993 / PGIII
• WGK Germany: 3
• RTECS: MI5215000
• HS Code: 29280000