A7837112
Tiagabine hydrochloride , ≥98%(HPLC) , 145821-59-6
Synonym(s):
(-)-(R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]nipecotic acid hydrochloride;(R)-(-)-1-[4,4-Bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid hydrochloride monohydrate;(3R)-1-[4,4-Bis(3-methyl-2-thienyl)-3-buten-1-yl]-3-piperidinecarboxylic acid hydrochloride;Tiagabine hydrochloride monohydrate
CAS NO.：145821-59-6
Empirical Formula: C20H26ClNO2S2
Molecular Weight: 412.01
MDL number: MFCD07369025
EINECS: 200-659-6
| Pack Size | Price | Stock | Quantity |
| 10MG | RMB103.20 | In Stock |
|
| 50MG | RMB359.20 | In Stock |
|
| 250MG | RMB873.60 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | >192oC dec. |
| alpha | D20 -11° |
| Flash point: | 9℃ |
| storage temp. | 2-8°C |
| solubility | H2O: soluble10mg/mL, clear |
| pka | pKa1 3.3; pKa2 9.4(at 25℃) |
| form | powder |
| color | white to beige |
| optical activity | [α]/D -9 to -12°, c = 1 in H2O |
| Water Solubility | water: soluble |
| Merck | 14,9417 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol, or distilled water may be stored at -20° for up to 3 months. |
| InChI | InChI=1/C20H25NO2S2.ClH/c1-14-7-11-24-18(14)17(19-15(2)8-12-25-19)6-4-10-21-9-3-5-16(13-21)20(22)23;/h6-8,11-12,16H,3-5,9-10,13H2,1-2H3,(H,22,23);1H/t16-;/s3 |
| InChIKey | YUKARLAABCGMCN-PKLMIRHRSA-N |
| SMILES | C(/C1SC=CC=1C)(=C/CCN1CCC[C@@H](C(=O)O)C1)\C1SC=CC=1C.Cl |&1:14,r| |
| CAS DataBase Reference | 145821-59-6(CAS DataBase Reference) |
Description and Uses
Tiagabine (145821-59-6) is a clinically useful anticonvulsant.1?It is also used to treat anxiety/panic disorder2?and neuropathic pain3. Tiagabine inhibits GABA-reuptake (IC50?[3H]GABA uptake = 67 nM)?via?inhibiting GABA transporter 1(GAT1) blocking both neuronal and glial GABA re-uptake.4,5
A GABA uptake inhibitor. Anticonvulsant.
Safety
| Symbol(GHS) |    GHS02,GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H225-H301+H311+H331-H370 |
| Precautionary statements | P210-P260-P280-P301+P310-P311 |
| Hazard Codes | Xn,T,F |
| Risk Statements | 20/21/22-39/23/24/25-23/24/25-11 |
| Safety Statements | 36/37-45-16-7 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| RTECS | TM6128245 |
| HS Code | 2934.99.3000 |
