Tetrabenazine , 98% , 58-46-8

Synonym(s):
9,10-Dimethoxy-1,3,4,6,7,11b-hexahydro-3-isobutyl-2H-benzo[a]quinolizin-2-one;Tetrabenazine, TBZ - CAS 58-46-8 - Calbiochem;VMAT2 Inhibitor, Xenazine

CAS NO.：58-46-8

Empirical Formula: C19H27NO3

Molecular Weight: 317.42

MDL number: MFCD00042740

EINECS: 200-383-6

PRODUCT Properties

• Melting point: 128-130?C
• Boiling point: 456.71°C (rough estimate)
• Density: 1.12
• refractive index: 1.5180 (estimate)
• storage temp.: 2-8°C
• solubility: DMSO: >10mg/mL
• pka: 6.46±0.40(Predicted)
• form: solid
• color: White
• Merck: 14,9182
• BRN: 40090
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
• InChI: InChI=1/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16H,5-7,10-11H2,1-4H3/t14-,16-/s3
• InChIKey: MKJIEFSOBYUXJB-UHFFFAOYSA-N
• SMILES: C12=CC(OC)=C(OC)C=C1CCN1[C@]2([H])CC(=O)[C@H](CC(C)C)C1 |&1:13,18,r|

Description and Uses

Tetrabenazine (58-46-8) is a potent inhibitor of the vesicular monoamine transporter (VMAT), IC50=3.2 nM with selectivity for VMAT2 over VMAT1. Promotes late stage differentiation of Pdx1-positive pancreatic progenitor cells into Neurog3-positive endocrine precursors.

Dopamine depleting agent. An antidyskinetic; antipsychotic.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312-P501
• Hazard Codes: Xn
• Risk Statements: 22
• Safety Statements: 24/25
• RIDADR: 3249
• WGK Germany: 3
• RTECS: DK2275000
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 29339900
• Hazardous Substances Data: 58-46-8(Hazardous Substances Data)