4-(6-Amino-3-pyridyl)piperazine-1-carboxylic Acid tert-Butyl Ester , ≥98.0%(HPLC) , 571188-59-5

CAS NO.：571188-59-5

Empirical Formula: C14H22N4O2

Molecular Weight: 278.35

MDL number: MFCD11594962

EINECS: 695-268-4

PRODUCT Properties

• Melting point: 130-132℃
• Boiling point: 454.1±45.0 °C(Predicted)
• Density: 1.182
• vapor pressure: 0-0Pa at 20-25℃
• storage temp.: Keep in dark place,Inert atmosphere,Room temperature
• solubility: DMSO (Slightly), Methanol (Very Slightly)
• form: Solid
• pka: 7.36±0.26(Predicted)
• color: Dark Yellow
• Sensitive: Air Sensitive
• InChI: InChI=1S/C14H22N4O2/c1-14(2,3)20-13(19)18-8-6-17(7-9-18)11-4-5-12(15)16-10-11/h4-5,10H,6-9H2,1-3H3,(H2,15,16)
• InChIKey: RMULRXHUNOVPEI-UHFFFAOYSA-N
• SMILES: N1(C(OC(C)(C)C)=O)CCN(C2=CC=C(N)N=C2)CC1
• LogP: 1.6-1.8 at 35℃ and pH7-9

Description and Uses

Tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate is a pharmaceutical intermediate compound that can be used to synthesize the targeted cancer drug Ribociclib for the treatment of ER-positive and HER2-negative breast cancer.

4-(6-Amino-3-pyridyl)-1-Boc-piperazine (tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate) is used as an organic chemical synthesis intermediate.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a
• HS Code: 2933599590
• REACH Registrations: Active