Tyrphostin AG 494 , >98.0%(HPLC)(N) , 133550-35-3
| Pack Size | Price | Stock | Quantity |
| 25mg | RMB375.20 | In Stock |
|
| 20MG | RMB376.00 | In Stock |
|
| 100MG | RMB1199.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 249 °C(dec.) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | DMSO: soluble |
| form | Yellow solid. |
| color | Light yellow to Amber to Dark green |
Description and Uses
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative, compounds that act as PTK blockers. PTK inhibitors that preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-
AG-494 (Tyrphostin AG 494) is a potent and selective EGFR tyrosine kinase inhibitor (IC50=0.7 μM). AG-494 inhibits the autophosphorylation of EGFR, ErbB2, HER1-2 and PDGF-R with IC50s 1.1, 39, 45 and 6 μM, respectively. AG-494 blocks Cdk2 activation and inhibits EGF-dependent DNA synthesis[1][2][3].
Safety
| Symbol(GHS) |   GHS06,GHS07 |
| Signal word | Danger |
| Hazard statements | H301-H315-H319 |
| Precautionary statements | P264-P270-P280-P301+P310+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P405-P501 |
| Safety Statements | 22-24/25 |
| RIDADR | 3439 |
| WGK Germany | 3 |
| HS Code | 2926.90.4801 |
| HazardClass | 6.1 |
| PackingGroup | III |
